1、制,本研究仅分析了 ACA 和 Anti2GPI 这两种抗体,狼疮凝固抑制物的检测和一些非标准化的抗磷脂抗体是否以及如何在两种疾病的诊断中发挥作用,仍值得进一步完善。临床实践发现:仅基于目前这 3 种APS 的实验室诊断标准存在一定不足和缺陷,不能满足临床的需求;还有其他抗体如抗蛋白 S 抗体、抗蛋白 C 抗体、抗凝血酶原抗体、抗磷脂酰乙醇胺抗体、抗波形蛋白抗体及抗膜联蛋白抗体在临床应用中的价值也是目前研究的一个方向22,会在以后的调查分析中加以关注和研究。综上所述,ACA 和 Anti2GPI 与复发性自然流产、子痫前期的发生有相关性,对孕妇不同型别的抗磷脂抗体检查十分必要。参考文献 1Mi
2、yakis S,Lockshin MD,Atsumi T,et al.International consensusstatement on an update of the classification criteria for definite an-tiphospholipid syndrome(APS)J J Thromb Haemost,2006,4(2):295306.2DIppolito S,Meroni PL,Koike T,et al.Obstetric antiphospholipidsyndrome:a recent classification for an old d
3、efined disorder J Autoimmun ev,2014,13(9):901908.3MartinezZamora MA,Tassies D,Carmona F,et al.Thrombin acti-vatable fibrinolysis inhibitor and clot lysis time in pregnant patientswith antiphospholipid syndrome:relationship with pregnancy outcomeand thrombosis J Am J eprod Immunol,2009,62(6):381389.4
4、陈晓辉,崔丽艳.抗磷脂抗体谱与病理妊娠 J 中华检验医学杂志,2018,41(12):9297.5Practice Committee of the American Society for eproductive Medi-cine.Definitions of infertility and recurrent pregnancy loss:a commit-tee opinion J Fertil Steril,2013,99(1):63.6ACOG practice bulletin.Diagnosis and management of preeclampsiaand eclamps
5、ia.Number 33,January 2002 J Obstet Gynecol,2002,99(1):159167.7Gibbins KJ,Tebo AE,Nielsen SK,et al.Antiphospholipid antibod-ies in women with severe preeclampsia and placental insufficiency:acasecontrol study J Lupus,2018,27(12):19031910.8Kaiser J,Branch DW.ecurrent pregnancy loss:generally acceptedc
6、auses and their management J Clin Obstet Gynecol,2016,59(3):464473.9Schreiber K,Hunt BJ.Pregnancy and antiphospholipid syndromeJ Semin Thromb Hemost,2016,42(7):780788.10Pelusa HF,Pezzarini E,Basiglio CL,et al.Antiphospholipid andantioangiogenic activity in females with recurrent miscarriage and an-t
7、iphospholipid syndrome J Ann Clin Biochem,2017,54(5):577583.11Opatrny L,David M,Kahn S,et al.Association between an-tiphospholipid antibodies and recurrent fetal loss in women withoutautoimmune disease:a meta analysis J J heumatol,2006,33(11):22142221.12陈铁福,张颖,孙倩,等.复发性流产与抗心磷脂抗体关系探讨 J 中国优生与遗传杂志,2008,
8、16(1):6768.13韦欣,叶剑锋,龚波.抗心磷脂抗体及抗 2糖蛋白 I 抗体的检测对不明原因流产妇女的诊断价值 J 血栓与止血学,2019,25(6):901902,905.14Skeith L,AbouNassar KE,Walker M,et al.Are antibeta 2 gly-coprotein 1 antibodies associated with placentamediated pregnancycomplications?A nested casecontrol study J Am J Perinatol,2018,35(11):10931099.15Gibbi
9、ns KJ,Mumford SL,Sjaarda LA,et al.Preconception an-tiphospholipid antibodies and risk of subsequent early pregnancy lossJ Lupus,2018,27(9):14371445.16王杜平,陈艳红,祖蓓蓓,等.2 种不同方法检测抗磷脂抗体的结果比较 J 临床检验杂志,2020,38(11):867868.17Heydarlou H,EghablFard S,Ahmadi M,et al.Investigation offollicular helper T cells,as a
10、 novel player,in preeclampsia J JCell Biochem,2019,120(3):38453852.18Stanhope TJ,White WM,Moder KG,et al.Obstetric nephrology:lupus and lupus nephritis in pregnancy J Clin J Am Soc Neph-rol,2012,7(12):20892099.19Marchetti T,de Moerloose P,Gris JC.Antiphospholipid antibodiesand the risk of severe and
11、 nonsevere preeclampsia:the NOHAcase control study J J Thromb Haemost,2016,14(4):675684.20de Jesus G,AgmonLevin N,Andrade CA,et al.14th Interna-tional Congress on Antiphospholipid Antibodies Task Force report onobstetric antiphospholipid syndrome J Autoimmun ev,2014,13(8):795813.21Pantham P,Abrahams
12、 VM,Chamley LW.The role of antiphos-pholipid antibodies in autoimmune reproductive failure J epro-duction,2016,151(5):7990.22翟晓丹,杨硕,崔丽艳.未纳入分类标准的抗磷脂抗体或可提高抗磷脂综合征诊断准确率 J 中华检验医学杂志,2021,44(4):347351.修回日期:2022-04-10本文编辑:薛丽萍中国妇幼保健杂志被国内数据库和检索性期刊收录情况中国妇幼保健杂志为 CCSE 中国权威学术期刊(A+)和中国期刊全文数据库、中国核心期刊(遴选)数据库及 中国生物医学文献数据库收录,并入选 中国学术期刊影响因子年报统计刊源期刊。674中国妇幼保健2023 年 2 月第 38 卷第 3 期Maternal and Child Health Care of China.February 2023,Vol.38,No.3