1、磁共振成像 2023年6月第14卷第6期 Chin J Magn Reson Imaging,Jun,2023,Vol.14,No.6http:/技术研究Technical Articles超高场7 T MRI对三叉神经及邻近血管的显示的应用研究毕京凤，刘欣瑶，张喆，荆京，隋滨滨*作者单位：首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心神经影像研究中心，北京 100070*通信作者：隋滨滨，E-mail：中图分类号：R445.2 文献标识码：A DOI：10.12015/issn.1674-8034.2023.06.010本文引用格式：毕京凤,刘欣瑶,张喆,等.超高场7 T MR
2、I对三叉神经及邻近血管的显示的应用研究J.磁共振成像,2023,14(6):66-70,84.摘要 目的探讨7 T MRI三维序列对三叉神经及邻近血管的显示效果。材料与方法前瞻性纳入2022年5月至2023年1月同时行7 T颅脑三维时间飞跃法磁共振血管成像（three dimensional time of flight magnetic resonance angiography,3D TOF MRA）、三维 T1 加权磁化准备 2 快速梯度回波（three dimensional T1-weighted magnetization prepared 2 rapid gradient ech
3、o,3D T1-MP2RAGE）序列和三维 T1 加权磁化准备快速梯度回波（three dimensional T1-weighted magnetization prepared rapid gradient echo,3D T1-MPRAGE）序列扫描的 24 例患者。由两位医生对三叉神经显示情况评分，并对 3D T1-MPRAGE和3D T1-MP2RAGE第二个反转时间生成的图像（3D T1-MP2RAGE GRETI2）三叉神经与邻近血管关系进行判读，比较两组图像的信噪比（signal to noise ratio,SNR）。采用Kappa检验评价两医生评分的一致性，采用2检验评价两
4、组图像判读结果的一致性，采用配对t检验比较两组图像的 SNR。结果两位医生对三组图像的评分一致性较好（Kappa值分别为 0.846、1.000和0.846）；两组图像三叉神经与邻近血管关系判读结果无差异（2=0.174，P0.05），3D T1-MP2RAGE GRETI2组SNR高于3D T1-MPRAGE组，分别为（62.1233.94）和（35.5215.32），差异有统计学意义（P0.001）。结论7 T颅脑三维MRI中，3D T1-MP2RAGE GRETI2图像SNR高于3D T1-MPRAGE，且图像上邻近血管显示为高信号易于观察，对三叉神经与邻近血管的显示优于3D T1-MP
5、RAGE和3D TOF MRA序列。关键词 三叉神经；磁共振血管成像；磁共振成像；信噪比The visualization of trigeminal nerve and its adjacent vessels using ultra-high field 7 T MRIBI Jingfeng,LIU Xinyao,ZHANG Zhe,JING Jing,SUI Binbin*China National Clinical Research Center for Neurological Disease Neuroimaging Center of Excellence,Beijing Ti
6、antan Hospital,Capital Medical University,Beijing 100070,China*Correspondence to:Sui BB,E-mail:Received 1 Feb 2023,Accepted 5 May 2023;DOI:10.12015/issn.1674-8034.2023.06.010ACKNOWLEDGMENTS Natural Science Foundation of Beijing(No.7212028).Cite this article as:BI J F,LIU X Y,ZHANG Z,et al.The visual
7、ization of trigeminal nerve and its adjacent vessels using ultra-high field 7 T MRIJ.Chin J Magn Reson Imaging,2023,14(6):66-70,84.Abstract Objective:To explore the visualization of trigeminal nerve and its adjacent vessels using 7 T MRI three dimensional sequences.Materials and Methods:Prospective
8、collection of 24 patients(48 trigeminal nerves in all)from May 2022 to January 2023,who underwent 7 T ultra-high-field cranial MRI.All patients were scanned with three dimensional time of flight magnetic resonance angiography(3D TOF MRA)sequence,three dimensional T1-weighted magnetization prepared 2
9、 rapid gradient echo(3D T1-MP2RAGE)sequence and three dimensional T1-weighted magnetization prepared rapid gradient echo(3D T1-MPRAGE)sequence.The original image data was assigned a score independently by two radiologists.The relationship of trigeminal nerve and its adjacent vessels with 3D T1-MPRAG
10、E images and images acquired at the second inversion time of 3D T1-MP2RAGE(3D T1-MP2RAGE GRETI2)were analyzed.Signal to noise ratio(SNR)of 3D T1-MPRAGE images and 3D T1-MP2RAGE GRETI2 images were compared.Kappa-test was used to compare the consistency of the scores.2 test was used to compare the rel
11、ationship results of trigeminal nerve and its adjacent vessels between 3D T1-MPRAGE images and 3D T1-MP2RAGE GRETI2 images.A Paired t-test was used to compare SNR between 3D T1-MPRAGE images and 3D T1-MP2RAGE GRETI2 images.Results:The Kappa values of the three groups of images were 0.846,1.000 and 0
12、.846,with good consistency.There was no difference between the two groups of sequences in displaying the relationship of trigeminal nerve and its adjacent vessels(2=0.174,P0.05).SNR of 3D T1-MP2RAGE GRETI2 sequence was higher than that of 3D T1-MPRAGE,(62.1233.94)and(35.5215.32)respectively.The diff
13、erence was statistically significant(P0.001).Conclusions:In 7 T ultra-high-field magnetic resonance brain imaging,3D T1-MP2RAGE GRETI2 images are better than 3D T1-MPRAGE images in displaying trigeminal nerve and its adjacent vessels,which have better SNR,and the adjacent vessels are easy to be obse
14、rved for their bright signals.Key words trigeminal nerve;magnetic resonance angiography;magnetic resonance imaging;signal to noise ratio0前言MRI已广泛应用于三叉神经脑池段的显示1-3，在3 T及以下场强的磁共振仪上常采用三维时间飞跃法磁共振血管成像（three dimensional time of flight magnetic resonance angiography,3D TOF MRA）序列进行观察，图像上三叉神经呈等信号，收稿日期：2023-0
15、2-01 接受日期：2023-05-05基金项目：北京市自然科学基金（编号：7212028）66磁共振成像 2023年6月第14卷第6期 Chin J Magn Reson Imaging,Jun,2023,Vol.14,No.6http:/技术研究Technical Articles脑脊液呈低信号，邻近血管呈高信号，可以较好地显示三叉神经脑池段与邻近血管的三维关系。但是该区域结构较复杂，受限于图像的信噪比（signal to noise ratio,SNR）以及空间分辨率，以往的 MRI 图像上三叉神经及其邻近血管的显示不够理想。近几年来，7 T超高场磁共振在颅脑的应用4，意味着更高的SNR
16、和空间分辨率，为清晰显示颅脑的细微结构提供了可能。很多学者在7 T超高场磁共振上对颅脑进行了大量研究5-7，其中3D TOF MRA序列对血管显示的研究多见8-12，但是其对三叉神经的显示鲜有报道。本文在7 T场强下研究了3D TOF MRA对三叉神经的显示情况，并分析了原因。同时对比了3D TOF MRA、三维 T1 加权磁化准备快速梯度回波（three dimensional T1-weighted magnetization prepared rapid gradient echo,3D T1-MPRAGE）序列和三维T1加权磁化准备2快速梯度回波（three dimensional T1-weighted magnetization prepared 2 rapid gradient echo,3D T1-MP2RAGE）序列三种常用的颅脑三维成像序列对三叉神经及其邻近血管的显示效果，旨在探索7 T超高场强下清晰显示三叉神经及其邻近血管结构的三维成像序列。1材料与方法1.1 一般资料选取2022年5月至2023年1月期间在天坛医院国家神经系统疾病临床医学研究中心进行7 T超高场
