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300199_2018_翰宇药业_2018年年度报告_2019-04-24.txt

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1、 2018 1 2018 2019 04 2018 2 2019, 2019 20184+7 1998 2019 2018 3 2019 2018 4 . 12 . 16 . 27 . 47 . 67 . 80 . 80 . 81 . 91 . 98 . 103 . 248 2018 5 1 2() 3 4 5 6 2018 6 / 2018 7 GMPGMP GMP FDA 2018 8 2018 9 PREDIKTOR MEDICAL ASSteinar Slid CFDA 2017 10 1 2 2018 10 Active Pharmaceutical Ingredients OTC

2、III III IV I II III IV BE GMP FDA DMF Drug Master File EDMF/ASMF Euro Drug Master File/Active Substance Master File EDMF/ASMF EDMF ASMF ANDA Abreviated New Drug Aplication 2018 11 ANDA ANDA ANDA ANDA 209 5 FDA II FDA 9 PCI 201ACFAHASCAIPCI -1(GLP-1) GLP-1 97% GLP-1 II 2018 12 3019 Hybio Pharmaceutic

3、al Co., Ltd. HYBIO 518057 518057 hy 075-2658036 075-2658036 075-2658078 075-2658078 hy hy htp:/ 2018 13 16 7 1101 26 2016-2018 2016 10 20144.2 2014 2018 2017 2016 1,264,4,507.22 1,246,23,503.67 1.46% 85,047,909.10 -340,79,346.41 329,721,380.16 -203.35% 291,924,689.16 -358,296,378.35 318,9,208.5 -212

4、.32% 265,203,014.20 46,98,356.82 28,557,348.14 -79.4% 296,411,74.75 / -0.37 0.36 -202.78% 0.3 / -0.37 0.35 -205.71% 0.3 -9.39% 8.96% -18.35% 9.85% 2018 2017 2016 5,60,297,821.60 5,298,007,460.5 6.84% 4,457,010,53.90 2018 14 3,391,680,347.8 3,84,84,327.4 -12.69% 3,604,587,764.32 928,267,040 / -0.3671

5、 268,64,174.45 378,27,285.03 258,165,736.82 359,407,310.92 98,247,987.79 111,564,606.56 83,76,690.13 -634,358,630.89 90,565,390.57 107,510,639.41 76,374,634.72 -632,747,043.05 98,438,239.28 4,343,417.5 89,912,384.84 -145,695,684.85 1 2018 15 2 2018 2017 2016 -13,242.41 -623,35.73 -349,129.85 3,2,413

6、.59 16,509,518.50 16,469,418.98 -13,29,123.51 -3,23,127.14 15,216,769.56 2,691,020.06 259,20.73 107,675.07 5,034,035.79 2,190,064.75 4,723,058.80 17,517,031.94 10,72,171.61 26,721,674.96 - 1 1 1 2018 16 /+ GLP-1 DPP-4 72,476.69 16.58% 8,68.43 73.3% EASL2017 80% 2018 17 T 3 ,724.85 21.62% 20 ,618,91

7、145.38% 12 ,568.88 3 .97 % 2015+ IDF2017 20 -79 4.25 2045 6.29 48% 40 209-2016 209 195 2016 606 17.79% 2018 18 209-2016 209 57.07 2016 25.90 21.72% 1 18 02 2 1 2018 19 2 203. 20 30MALDI-TOF-TOF ESI-MS 30 3 20 9 17 + 4 10% 2018 20 100%GMP GMP FDA 5 + 6 1 2018 11 3ml:18mg 6 International Diabetes Fede

8、rationIDF201720 -79 4.25 2018 21 II 3.52 2045 6.2920 -79 2017 1.142045 1.5 1000 50 5 2017 38 2 2018 11 15 MFDS 2018-A1 -1737 3 2018 12 0.25mg 6 H20183468 2023 11 20 GnRHGnRH-A LHRH(LH)(FSH) GnRHGnRH-aGnRH-A GnRH-a GnRH-A OHSS GnRH-a 2018 2 GnRH-A GnRH-A GnRH -a 4 1.6mg 6 H20193037 2024 01 31 2017201

9、5 20102010208 5 2018ZX0930302 2018 1 -2020 12 2,80 4802018 14 FDA 3 ANDAPAI 2018 23 62018 2018 8 17 2015 20182018 7 2018 12 31 170 16 3 82 24 1 ZL 2013 1 0676431.5 2013- 12- 1 2 ZL 2013 1 0198564.6 2013- 0 5 - 24 3 ZL 2013 1 082987.1 2013- 0 3 - 15 4 ZL 2013 1 039263.8 2013- 0 9 - 0 2 5 ZL 2013 1 01

10、20693.3 2013- 0 4 - 0 9 6 ZL 2013 1 071725.5 2013- 12- 20 7 DiaPep27 ZL 2013 1 0585416.X 2013- 1- 19 8 ZL 2013 1 0717379.3 2013- 12- 20 9 ZL 2014 1 028375.7 2014- 0 6 - 23 10 ZL 2014 1 078495.9 2014- 12- 17 1 ZL 2014 1 072052.6 2014- 12- 0 2 12 ZL 2015 1 036731.6 2015- 0 6 - 29 13 ZL 2015 1 019451.1

11、 2015- 0 3 - 18 14 ZL 2013 1 067474.8 2013- 12- 1 15 ZL 2014 1 0290468.9 2014- 0 6 - 24 2018 24 16 ZL 2013 1 041018.4 2013- 0 9 - 10 17 serelaxin ZL 2014 1 0105936.0 2014- 0 3 - 20 18 ZL 2013 1 0432612.3 2013- 0 9 - 2 19 UPLC ZL 2014 1 0290469.3 2014- 0 6 - 24 20 ZL 2014 1 0841069.7 2014- 12- 30 21

12、ZL 2015 1 064104.2 2015- 0 9 - 30 2 ZL 2014 1 0504852.4 2014- 0 9 - 26 23 - 2 - 2 ZL 2014 1 07675.X 2014- 0 3 - 0 4 2 4 - N - ZL 2015 1 0364.4 2015- 0 6 - 29 6 1 ZL 2015 1 10974.0 2015- 12- 29 2 N,N- ZL 2015 1 0148254.2 2015- 0 3 - 31 3 ZL 2014 1 049537.7 2014- 0 9 - 25 4 ZL 2013 1 0375935.3 2013- 0

13、 8 - 26 5 ZL 2015 1 0631805.0 2015- 0 9 - 29 6 ZL 2014 1 078926.3 2014- 12- 15 2 1 ZL 2014 1 0184687.9 2014- 05- 04 2 D ZL 2014 1 0129.8 2014- 03- 24 2 2018 25 1 ZL 2017 2 0503514.8 2017- 05- 08 2 ZL 2016 1 04632.6 2016- 06- 23 5 1 ZL 2017 2 092429.2 2017- 08- 10 2 ZL 2017 2 0845134.2 2017- 07- 12 3

14、 ZL 2018 3 045271.1 2018- 08- 15 4 ZL 2017 1 0675780.3 2017- 08- 09 5 ZL 2017 2 0979435.4 2017- 08- 08 2018 12 31 8 4 4 2 1 EP2537856B1 2012- 08- 16 2 EP2915817B1 2012- 10- 31 10 2018 12 31 181 39 10 1 4 1 259490 1 2018.08.21- 2028.08.20 2 24267659 35 2018.05.21- 2028.05.20 3 24267658 1 2018.05.14-

15、2028.05.13 4 24267657 35 2018.08.28- 2028.08.27 7 1 IDM0520913 1 2013.1.29- 2023.1.29 2018 26 2 IDM0521543 5 2013.1.29- 2023.1.29 3 IDM0527394 35 2013.1.29- 2023.1.29 4 84072579 1 2016.08.09- 2026.08.09 5 840725809 5 2016.08.09- 2026.08.09 6 840725825 35 2016.08.09- 2026.08.09 7 1230635 1 5 35 2013.

16、1.21- 2023.1.21 1 1 140176 10 2017.1.27- 2027.1.27 2018 27 20182018 126,4.45 1.46% 52,84.02 -34 ,07.93 -20 3.35% 2018 19 ,121.5 15.12 % 83.72% 20 19 8 2010GnRHGnRH-A(IVF) 60% IVF 35 35 -40 IVF 50% 2018 28 2018 7 10ml:20mg2019 1 CYHB19501352019 2 CYHB19501912019 2 7 2017 9 CFDA2018 11 1 6 BE 2 6 BE 3

17、 6 BE 4 6 BE 5 6 BE 6 6 7 6 8 3.1+6 9 3.1+6 10 3.1+6 11 3.1+6 2018 29 12 3.1+6 13 3.1 14 3.1 15 3.1 16 3.1 BE 17 3.2 BE 21 3 II 2 4 BE BE 23 4 24 HY42 4 25 4 26 4 27 4 BE 2018 5 37.5mg/5ml EMA2018 11 MFDS 2019 3 TEVA2018 42.5 2018 30 1 II DMF API 2 II DMF API 3 II DMF API 4 II DMF API 5 EDMF/ASMF AP

18、I 6 EDMF/ASMF API 7 DMF API 8 DMF API 9 II DMF API 10 ANDA 11 MAA 12 ANDA 13 ANDA II 2010 GMP cGMP GMP 2015 cGMP2018 3 FDA cGMP 2017 ANVISA cGMP2018 4 12 GMP2018 GMP 2018 11 TOPILORIC2013 6 28 2018 31 2017 10.32012 2017 45.68% 5 2018 21 ,964.84 37.68% 9,37.32 54.41% 2019 20182018 1 2 1 2018 2017 1,2

19、64,4,507.22 10% 1,246,23,503.67 10% 1.46% 1,264,4,507.22 10.0% 1,246,23,503.67 10.0% 1.46% 724,76,916.8 57.32% 621,698,723.42 49.89% 16.58% 146,759,69.57 11.61% 117,6,652.07 9.4% 24.72% 239,191,951.37 18.92% 18,941,117.59 15.16% 26.60% 2018 32 57,654,011.01 4.56% 52,831,563.98 4.24% 9.13% 194,47,027

20、.35 15.38% 212,247,432.24 17.03% -8.37% 86,684,257.58 6.86% 50,011,957.54 4.01% 73.3% 125,68,759.12 9.94% 190,349,359.64 15.27% -3.97% 206,189,080.83 16.31% 84,028,101.17 6.74% 145.38% 7,41,678.37 0.59% 2,42,878.79 0.19% 207.14% 90,104,713.3 7.13% 13,782,820.47 10.73% -32.65% 104,797,167.59 8.29% 21

21、0,59,869.93 16.90% -50.23% 5,456,191.10 0.43% 3,391,750.25 0.27% 60.87% 196,86,740.27 15.57% 316,512,685.84 25.40% -37.80% 159,393,561.23 12.61% 172,847,89.90 13.87% -7.78% 139,509,797.45 11.03% 189,165,258.85 15.18% -26.25% 30,742,320.85 23.78% 205,086,9.82 16.46% 46.64% 130,683,573.74 10.34% 85,31

22、,671.60 6.85% 53.15% 37,248,513.68 26.67% 27,28,97.6 2.25% 21.62% 126,4.451.46% 2018 3,724. 8 5 2 1 .62 % 2 01872,476. 6916.58%201821,964.8437.68%9,37.3254.41% 2 10% 1,264,4,507.22 182,526,94.60 85.56% 1.46% -7.25% 1.36% 2018 3 724,76,916.8 113,370,939.86 84.36% 16.58% 11.08% 0.7% 146,759,69.57 23,9

23、47,821.42 83.68% 24.72% 13.9% 1.54% 239,191,951.37 49,712,50.86 79.2% 26.60% 23.81% 0.47% 57,654,011.01 19,674,152.60 65.8% 9.13% 39.25% -7.38% 194,47,027.35 6,425,72.59 96.70% -8.37% -17.21% 0.35% 86,684,257.58 13,611,023.09 84.30% 73.3% -28.42% 2.32% 125,68,759.12 21,789,989.84 82.6% -3.97% -4.83%

24、 3.41% 206,189,080.83 6,726,907.42 96.74% 145.38% 64.73% 1.60% 7,41,678.37 1,84,576.4 74.68% 207.14% 205,137.89% -25.29% 90,104,713.3 23,571,520.0 73.84% -32.65% -27.78% -1.7% 104,797,167.59 8,234,836.14 92.14% -50.23% -40.31% -1.31% 5,456,191.10 6,948,24.90 -27.35% 60.87% 47.56% 11.45% 196,86,740.2

25、7 2,696,87.24 8.47% -37.80% -43.94% 1.26% 159,393,561.23 24,323,610.27 84.74% -7.78% -12.6% 0.85% 139,509,797.45 30,468,291.95 78.16% -26.25% 13.53% -7.65% 30,742,320.85 56,491,239.97 81.2% 46.64% 46.5% 0.01% 130,683,573.74 19,101,310.31 85.38% 53.15% 0.67% 7.62% 37,248,513.68 29,45,654.86 91.27% 21

26、.62% -3.2% 7.17% 1 3 2018 2017 16,795,943 16,631,451 0.9% 16,873,727 15,265,495 10.54% 861,605 1,593,786 -45.94% 2018 34 3 ,340,385.50 15,848,050.5 110.38% 3,379,915.5 15,858,50.4 110.49% 9,093,812.3 9,093,812.3 0.0% 10,697,24 30,348,419.26 -64.75% 2,743,697 45,81,479 -50.43% 19,359,089.52 13,871,76

27、0.84 39.56% 3,507,602 5,265,811 -3.39% 3,347,75 5,306,95 -36.92% 147,430 319,471 -53.85% 1,206,523 2,142,0 -43.67% 1,704,240 2,620,406 -34.96% 1,043,542 568,215 83.65% 1,584,057 1,219,784 29.86% 1,380,475 1,461,684 -5.56% 153,470 396,901 -61.3% 30% 1 2 3 4 5 6 4 5 2018 35 2018 2017 25,759,485.49 14.

28、11% 27,895,924.48 14.18% -7.66% 9,074,893.50 4.97% 6,65,390.51 3.38% 36.35% 78,536,560.87 43.03% 67,514,270.48 34.31% 16.3% 113,370,939.86 62.11% 102,065,585.47 51.87% 11.08% 4,630,254.76 2.54% 2,03,60.84 1.03% 127.69% 1,53,934.2 0.85% 1,241,750.02 0.63% 25.14% 542,718.4 0.30% 808,215.17 0.41% -32.8

29、5% 6,726,907.42 3.69% 4,083,56.03 2.08% 64.73% 6,054,694.61 3.32% 8,391,521.75 4.26% -27.85% 1,892,13.24 1.04% 3,584,638.35 1.82% -47.2% 13,843,161.99 7.58% 27,522,311.03 13.9% -49.70% 21,789,989.84 11.94% 39,498,471.13 20.07% -4.83% 6,145,976.15 3.37% 10,373,315.75 5.27% -40.75% 2,837,308.54 1.5% 3

30、,759,756.29 1.91% -24.53% 14,588,235.31 7.9% 18,503,180.53 9.40% -21.16% 23,571,520.00 12.91% 32,636,252.57 16.58% -27.78% 6,689,976.10 3.67% 11,585,143.8 5.89% -42.25% 646,147.94 0.35% 641,046.3 0.3% 0.80% 898,712.10 0.49% 1,570,209.67 0.80% -42.76% 8,234,836.14 4.51% 13,796,39.88 7.01% -40.31% 2,2

31、61,582.58 1.24% 1,608,493.68 0.82% 40.60% 1,64,919.69 0.91% 748,305.01 0.38% 12.49% 3,021,72.63 1.6% 2,351,825.71 1.20% 28.48% 6,948,224.90 3.81% 4,708,624.40 2.39% 47.56% 1,84,576.4 1.03% 6 2018 4 11 6,0(,) 2018 36 7 8 361,705,637.31 28.61% 0.0% 5 1 145,836,795.82 11.53% 2 85,365,502.9 6.75% 3 5,07

32、3,807.60 4.36% 4 43,50,689.4 3.4% 5 31,928,841.46 2.53% - 361,705,637.31 28.61% 40,710,347.32 34.84% 5 1 12,637,02.81 10.82% 2 10,404,172.41 8.90% 3 7,748,269.98 6.63% 4 5,083,136.92 4.35% 5 4,837,765.20 4.14% - 40,710,347.32 34.84% 2018 37 3 2018 2017 603,94,839.60 408,606,67.64 47.81% 154,167,276.

33、0 116,464,387.81 32.37% 8,83,683.23 16,087,473.27 -4.78% 94,894,165.98 89,416,514.34 6.13% 4 2018 2017 2016 307 236 254 28.9% 25.46% 29.67% 191,215,472.53 102,610,901.13 89,29,49.10 15.12 % 8.23% 10.4% 96,321,306.5 13,194,386.79 28,864,408.29 50.37% 12.86% 32.35% -28.27% 3.92% 9.89% 10 - 1 2018 38 1

34、 2 3 4 2 1 2016-11 -02 2 20 23 -04 -19 3 20 23 -04 -19 4 20 23 -07 -18 5 202-11 -15 6 2020-01 -06 7 2020-03 -08 8 I II 2020-03 -08 9 202-09 -24 10 3.0ml 2023-05 -09 11 3.0ml 2024-03 -28 3 2018 39 11 10 1 5 2018 2017 1,207,947,394.12 1,085,807,970.22 11.25% 1,160,949,037.30 857,250,62.08 35.43% 46,98

35、,356.82 28,57,348.14 -79.4% 5,715,725.0 327,615.20 1,64.65% 425,575,783.90 23,816,116.36 90.15% -419,860,058.90 -23,48,501.16 -87.87% 1,753,478,120.01 731,863,80.15 139.59% 1,098,895,241.84 38,670,485.47 24.47% 654,582,878.17 393,193,394.68 6.48% 295,76,961.51 387,923,090.10 -23.75% 1 35.43% 79.4% 2

36、 164.65% 3 90.15% 4 87.87% 5 139.59% 18 02 6 24.47% 15 01 7 6.48% 18 02 2018 40 6,45,653.42 -1.97% 58,75,574.95 16 7.43% 21,852.11 -0.07% 13,626,783.5 4.15% 1 2018 2017 1,564,241,375.10 27.61% 1,268,464,413.59 23.94% 3. 67 % 1,231,757,062.39 21.74% 1,083,616,549.58 20.45% 1. 29 % 161,616,709.18 2.8

37、5% 142,814,591.11 2.70% 0.1 5% 117,945,980.51 2.08% 110,014,93.97 2.08% 71,879,2.40 13.63% 803,491,711.70 15.17% -1.5 5% 56,104,317.91 9.82% 256,374,473.31 4.84% 4.98% 409,0,0.0 7.2 2% 319,80,0.0 6.04% 1.1 8% 850,425,70.16 15.01% 25,78,839.3 4.83% 10.18% 2 3 329,123,311.79 184,817,24.85 2018 41 10,8

38、0,592.61 248,970,3.35 73,711,462.60 - 1 60,0,0.0 0.0 10.0% 2 30,0,00.0 50.0% 5 0.0 201904 09 2019-030 30,0,00.0 50.0% 5 0.0 201811 10 2018-107 - - 60,0,00.0 - - - - - 0.0 - - - 3 2018 42 4 5 1 2011 IPO 71,502.58 1,307.59 69,642.41 0 0 0.0% 1,860.17 - 0 2015 40,870.0 40,870.0 0 0 0.0% 0 2016 64,507.7

39、9 31.02 63,527.91 0 0 0.0% 979.8 0 - 176,80.37 1,638.61 174,040.32 2,840.05 - 0 2018 12 31 1,740,403,201.72018 16,386,093.42 1,724,017,108.28 28,40,538.79 2018 12 31 53,831,236.73 25,430,697.94 47,354,481.97 21,263,27.01 2013 10 18 628,349.35 32,207.67 2 () (1) (2) (3)(2)/(1) 1 28,30 48,789 0 50,218

40、.29 102.93% 201312 31 -12,114.45 2,746.41 2 3,130 4,0 0 4,205.1 105.13% 20 13 2018 43 12 31 310% 40,870 40,870 0 40,870 10.0% 9,37.32 58,270.85 4 6,279.6 6,279.6 31.02 5,242.51 83.48% 5 58,28.19 58,28.19 0 58,285.4 10.10% - 136,807.79 158,16.79 31.02 158,821.3 - - -2,7.13 61,017.26 - - 1 21 9,0 9,0

41、5,564 61.82% 201412 31 2 4,0 4,0 1,307.59 3,941.4 98.54% 201412 31 12,095.53 32,320.35 - 5,713.58 5,713.58 5,713.58 - - - - - - 18,713.58 18,713.58 1,307.59 15,219.02 - - 12,095.53 32,320.35 - - - 15,521.37 176,80.37 1,638.61 174,040.32 - - 9,318.40 93,37.61 - - 1 2 21 1 21 9,0 2018 12 31 5642 4,0 1

42、,0 5,0 6,0CyclosetBromocriptine 2018 4 2018 12 31 3941.4 3 2013 3 13 2013 4 12 ,2012 20,489 870 4 2013 10 18 5,713.58 14.26% 7.9% 2,126.32 1414.57 2011 3 21 3 1 2018 45 2 10% 29,090,0.0 941,84,31.74 912,923,494.8 219,648,404.91 111,896,981.86 93,373,21.95 HKD60,0,0.0 864,461,06.91 84,809,60.38 37,31

43、2,301.53 215,173,143.01 215,172,89.47 2018 46 1 2018 01 09 2018-01 2018 01 15 2018-02 2018 06 30 2018-03 2018 07 04 2018-04 2018 08 16 2018-05 2018 10 12 2018-06 2018 47 10 0 10 0 10 0 928,267,040 0 9,972,401.02 9,972,401.02 -63 ,192,396.3 10% 2018 2 11 2018 2 28 2018 1 1 5,05,0 2018 8 28 6,275,50 0

44、.067% 9,972,401.0220192 2018 2018 48 9,972,401.02 2018 2018 -35,734,213.18 2018 12 31 -63 ,192,396.33 2018 2018 6,275,50 9,972,401.02 3 1 2016 2017 20162016 12 31 918,342,540 10 1.0 91,834,254.0 2 2017 2018 20172017 12 31 934,692,540 10 2.0 186,938,508.0 3 2018 2019 2018 2018201922 2018 49 2018 6,27

45、5,50 9,972,401.02 2018 0 -35,734,213.18 0% 9,972,401.02 -29.78% 9,972,401.02 -29.78% 2017 186,938,508.0 329,721,380.16 56.70% 0 0 186,938,508.0 56.70% 2016 91,834,254.0 291,924,689.16 31.46% 0 0 91,834,254.0 31.46% 1 1 2 1 2014 08 20 1. 2. 2018 4 20 2017 2018 50 3,73.6 1 2/ 2 2011 04 07 1 2PINXIANG

46、YU SANYOU CHEN 3 3 2016 10 17 36 1 234PINXIANG YU SANYOU 25% 2018 51 CHEN 5 SANYOU CHENPINXIANG YU 20183,0 2018 10 26 2019 7 26 20194 8 3 201810 2018 10 26 2019 7 26 20194 8 3 1 2015 2 10 12 2018 52 1 2015 20142015 1.11.485 20162017 1.932.413 2 1 2015 20141.1 201420151.11.485 201420152014 20161.11.4

47、851.93 2014 2015 2016 2014 2015 20171.11.4851.932.413 2014 201520162017 2014 2015 2016 2017 5 31 2,362.57 2016 2 2015 2015 2018 53 3 30 = 3 123/ 2018 54 2 / 25%/ 2010 3 12 206-207208-2010 A 2012 5 35.36 2010 11 29 3 2018 5 15,450642 1 7,797,639 2 5,21,459 3 2,02,360 5 1 429,184 36 36 12,875,536 36 3

48、6 2 1 2018 6 15 2018201815 1 2018 56 2 3 4 5 6 7 8 9 2018 4 1 6,0( , ) 158 3 3 2018 57 4,90 0 2018 12 31 1 2 2019 3 211231612042mg 90.0-110.0%1112316120410402 4,960,094.213 5,037,70.4 23 9,97,864.612019 4 15 2019-036 GMP20182mg 2019 4 10 2018 58 2015 5 14 27,0 1 12016 10 17 1 429,184 9,9,987.20 2017

49、 3 7 2017 3 2 2017 2,10 1,825 275 2017 3 24 2017 3 24 64 1,820 2017 6 12 20176 13 60 56 1,635 2017 3 24 918,342,540.0 934,692,540.0 2018 5 31 2018 6 13 2018 59 150,0 16,20,0 11,340,0 2018 2018 11 8 525,0 52 10,815,0 2018 2019 3 13 52 10,815,0 8.74/ 9,452.31 927,742,040 916,927,040 2019 1 6.8/ 1,056.

50、92 10.0% 1, 50 - 201803 16 2018-02 4.6 4 / 11.72 0.10% 50 - 201803 16 2018-02 2018 60 2 3 4 5 1 1 2 3 2 2018 61 1 2017 6 30 20,0.0 2017 6 30 15,0.0 2016 10 26 67,50.0 2016 12 20 67,50.0 B1 0 B2 0 B3 102,50.0 B4 67,50.0 A1+B1+C1 0 A2+B2+C2 0 A3+B3+C3 102,50 A4+B4+C4 67,50 A4+B4+C4 19.90 % D 67,50.0 70%E - 50%F - D+E+F 67,50.0 2018 62 - - 2 3 1 2 4 1 2 3 N/A N/A N/A 2016 868.5 N/A 2018 63 COD 1 34.5 345 0.5187 8.42 BOD 1 18.3 150 0.230 N/A PH 1 6.8 -7.5 69 - N/A 1 0.2 35 0.0361 0.85 1 0.105 5.2 0.081 0.127 1 0.02 50 0.0237 0.039 VOCS 1 8.6 120 0.15

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