1、 基金项目国家自然科学基金项目(81873187,82274474);中原领军人才(ZYYCYU202012119);国家中医临床研究基地科研专项(2022JDZX007)作者单位1.河南中医药大学第一临床医学院,河南 郑州 450000;2.河南中医药大学第一附属医院艾滋病临床研究中心,河南 郑州450000;3.河南省病毒性疾病中医药防治重点实验室,河南 郑州 450000 通信作者郭会军,E-mail:网络首发时间 2022-11-1713 18 网络首发地址https:/ 年 3 月第 37 卷第 3 期Mar.2023,Vol37,No3319http:/性传播疾病不同时期河南省某地
2、区 HIV/AIDS 患者生存质量比较徐赫文1,金艳涛2,李鹏宇2,王东利1,贾皇超1,巩仪凡1,郭会军2,3 摘要 目的比较不同时期河南省艾滋病高发地区 HIV/AIDS 患者的生存质量差异,以期为其治疗和随访管理的措施制订提供参考。方法采用回顾性研究,选择课题组 2013 2014 年、2021 年对河南省艾滋病高发地区所做的抽样调查为病例来源,提取两组 HIV/AIDS 患者人口学信息、疾病相关信息及 WHOQOL HIV-BEF 中文版量表数据。其中,以 2013 年 12 月 2014 年 8 月调查的 HIV/AIDS 患者为前期组,2021 年 3 月 2021 年 4 月调查的
3、 HIV/AIDS 患者为现期组。利用倾向性评分匹配法来控制组间差异后,采用 t 检验比较匹配后的现期组与前期组、现期组与常模的生存质量差异。结果本研究共纳入 2 186 例 HIV/AIDS 患者,其中前期组HIV/AIDS 患者 1 045 例,现期组 HIV/AIDS 患者 1 141 例。经倾向性评分进行1 1匹配后共得到295 对病例,组间差异均无统计学意义(P 0.05)。匹配后的现期组与前期组比较时,现期组在生存质量总分、心理领域、独立性领域、社会关系领域、环境领域的得分高于前期组(P 0.05);精神/支柱/个人信仰领域的得分低于前期组(P 0.05);两组生理领域的得分差异无
4、统计学意义(P 0.05)。匹配后的现期组与常模比较时,现期组在生理领域、心理领域、社会关系领域的得分低于常模(P 0.05);在独立性领域、环境领域、精神/支柱/个人信仰领域的得分高于常模(P 0.05);两组生存质量总分的差异无统计学意义(P 0.05)。结论河南省 HIV/AIDS 患者的生存质量较前有所提高,与常模比,在生理、心理、社会关系领域方面仍有待提高。由于本回顾性研究的局限性,研究结果有待进一步证实。关键词 真实世界;艾滋病;生存质量;倾向性评分 中图分类号 751;512.91 文献标志码 B 文章编号 1001 7089(2023)03 0319 06 DOI 10 137
5、35/j cjdv1001-7089 202207148Comparison of Quality of Life of HIV/AIDS Patients in a Certain Area of Henan Province inDifferent PeriodsXU Hewen1,JIN Yantao2,LI Pengyu2,WANG Dongli1,JIA Huangchao1,GONG Yifan1,GUO Huijun2,3(1.The First Clinical Medical School,Henan University of Traditional Chinese Med
6、icine,Zhengzhou450000,China;2.Acquired Immune Deficiency Syndrome Treatment and esearch Center,the FirstAffiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;3.Henan Key Laboratory of Viral Disease Prevention and Treatment of Traditional Chinese Medicine,Zhen
7、gzhou 450000,China)http:/ Corresponding author GUO Huijun,E-mail: AbstractObjectiveTo compare the differences in quality of life(QOL)of HIV/AIDSpatients in different periods in areas with high incidence of AIDS in HenanProvince,to provide reference for the treatment and follow-up managementmeasures
8、MethodsA retrospective study was conducted to select the samplesurveys conducted by the research group in the high incidence areas of AIDS inHenan Province from 2013 to 2014 and 2021 as the source of cases.Thedemographic and disease-related information of two groups of HIV/AIDS patients andthe Chine
9、se version of WHOQOL HIV-BEF scale data were extracted.Among them,the HIV/AIDS patients surveyed from December 2013 to August 2014 were the earlygroup,and the HIV/AIDS patients surveyed from March 2021 to April 2021 were thecurrent group.After controlling the differences between groups by propensity
10、 scorematching method(PSM),and differences in QOL of the matched patients betweenthe current group and the early group as well as between the current group and thenational norm group were compared by t-test esultsA total of 2 186 HIV/AIDSpatients were included in this study,including 1 045 HIV/AIDS
11、patients in the earlygroup and 1 141 HIV/AIDS patients in the current group.A total of 295 pairs ofcases were matched by 1 1 PSM,and there was no significant difference in baselineinformation between groups(P 0.05).When comparing the matched current groupwith the early group,the overall scores of QO
12、L,psychological domain,independentdomain,social domain,and environmental domain of HIV/AIDS patients in thecurrent group were higher than those in the early group(P 0.05).The score ofspiritual/pillar/personal belief was lower than that in the early group(P 0.05).There was no significant difference i
13、n physiological score between the two groups(P 0.05).When comparing the matched current group with the national normgroup,the scores in physiological,psychological,and social relation domains werelower than those of the national norm group(P 0.05),and the scores inindependent,environmental,spiritual
14、/pillar/personal belief domains were higherthan those of the national norm group(P 0.05).There was no significant differencein overall scores of QOL between the two groups(P 0.05)ConclusionThe QOLof HIV/AIDSpatientsinHenanProvincehasimproved,andthephysical,psychological,social relations still need t
15、o be improved compared with the norm.Dueto the limitations of this retrospective study,the results need to be further confirmed.Key words eal world;HIV/AIDS;Quality of life;Propensity score艾滋病即获得性免疫缺陷综合征(acquiredimmunodeficiency syndrome,AIDS),是由人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染引起的一种以人体免疫
16、系统受损为特征的致死性传染病1,临床上患者易发生各种机会性感染和肿瘤,预后较差。近年来,随着河南省艾滋病抗机会性感染治疗政策的推广和免费抗反转录病毒治疗(antiretroviral therapy,AT)政策的实施,有效降低了艾滋病病毒(HIV)感染者/艾滋病(AIDS)患者(简称 HIV/AIDS 患者)的发病率和死亡率,使HIV/AIDS 患者的生存时间得以延长2,因此与HIV/AIDS 患者健康相关的生存质量受到众多临床医生的关注。生存质量是指不同文化、价值体系中的个体对与自己目标、期望、标准以及所关心的事情有关的生存状况的主观体验3,包括个体生理、心理、社会、独立性、环境、精神/支柱/个人信仰 6 大领域4,是对健康的多维度评价。目前已经成为艾滋病研究领023中国皮肤性病学杂志 2023 年 3 月第 37 卷第 3 期Chin J Derm Venereol,Mar.2023,Vol.37,No.3徐赫文,金艳涛,李鹏宇,等 不同时期河南省某地区 HIV/AIDS 患者生存质量比较http:/域中除生存期、病死率、CD4+T 细胞计数及病毒载量等之外,较为常用的疗效评价指标