1、T Cell Immune Checkpoints Chimerigen LaboratoriesCMMAY Regulation and activation of T lymphocytes depend on signaling by the T cell receptor(TCR)and also by cosignaling receptors that deliver negative()or positive(+)signals.APC/Tumor cell/Dendritic cellT cell?CD28PD-1 CD279CTLA-4 CD152+PD-L1 B7-H1;C
2、D274 or PD-L2 B7-DC;CD273CD80 B7-1 or CD86 B7-2ICOS CD278+ICOSL B7-H2;B7RP1;CD275?B7-H3 CD276/B7-H4 VTCN1?TMIGD2 IGPR-1?VISTA B7-H5;PD-1H;Gi24B7-H7 HHLA2Cytokines(TGF,IL-1,IL-6,IL-10,IL-12,IL-18)|Tryptophan|IDO1,TDO+?Butyrophilin Family Members(e.g.Btnl2,Skint1,MOG,CD277)BTLA CD272CD137 TNFRSF9;4-1B
3、BOX40 TNFRSF4;CD134CD27 TNFRSF7CD40L TNFSF5;CD154+GITR TNFRSF18;CD357CD96CD155 PVR;Necl-5CD226 DNAM-1TIGITCD112 PVRL2;Nectin-2CD112RCD200R2B4 CD244CD200CD48 BCM-1;BLAST-1GITRL TNFSF18HVEM TNFRSF14;CD270CD137L TNFSF9;4-1BBL OX40L TNFSF4;CD252CD70 TNFSF7;CD27LCD40 TNFRSF5TIM-3 HAVcr-2Gal-9A2aRAdenosineKIRLKIRSTCRLAG-3 CD223PeptideSIGNALMHC class I or IIREVIEWS:Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity:A.G.Ramsay;Br.J.Haematol.162,313(2013)Immune checkpoint blockade:a common denominator approach to cancer therapy:S.L.Topalian,et al.;Cancer Cell.27,450(2015)
