1、安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2023 Feb,27(2)及影响因素分析 J .中华疾病控制杂志,2015,19(8):854-856.8 陈彬,王晓萌,顾华,等.浙江省学生肺结核患者发现延误影响因素分析 J.中国学校卫生,2013,34(11):1339-1341.9 傅丽娟,汪业胜,朱文龙,等.湖州市2008-2018年肺结核患者就诊延迟情况及影响因素 J.中华疾病控制杂志,2021,25(2):235-239.10陈松华,王晓萌,钟节鸣,等.肺结核病新患者发现延误及影响因素分析 J.中国公共卫生,2013,29(4):4
2、81-484.11赵燕,张天华,柳巍,等.陕西省2015年肺结核患者就诊延迟及其相关因素分析 J.中国热带医学,2017,17(3):289-292.12毛宁,钟威,梁爽,等.辽宁省2017年肺结核患者就诊延迟相关因素分析 J.中国热带医学,2020,20(1):61-64.13赵秀秀,徐凌忠,郭振,等.肺结核病人就诊延迟影响因素分析J.中国卫生事业管理,2012,29(10):795-797.14XU X,LIU JH,CAO SY,et al.Delays in care seeking,diagnosis and treatment among pulmonary tuberculosi
3、s patients in Shenzhen,China J.The International Journal of Tuberculosis and Lung Disease,2013,17(5):615-620.15TONG Y,GUAN X,HOU S,et al.Determinants of health care-seeking delay among tuberculosis patients in rural area of central China J.Int J Environ Res Public Health,2018,15(9):1998.16魏建军,曾令霞.20
4、142017年陕西汉中市肺结核患者就诊延迟及影响因素 J.公共卫生与预防医学,2018,29(5):55-58.17胡洁,顾伟玲,王远航,等.2010-2019年浙江省嘉兴市学生肺结核患者发现延误及其影响因素分析 J.疾病监测,2021,36(10):1021-1024.18李德洋,苏德奇,张为胜,等.乌鲁木齐市肺结核患者就诊、确诊、发现延迟的影响因素分析 J.预防医学,2020,32(11):1150-1154.(收稿日期:2021-11-04,修回日期:2021-12-26)超脉冲二氧化碳点阵激光联合黄金微针射频治疗面部痤疮凹陷性瘢痕的疗效观察李小燕1,聂磊1,郭伟1,程绍航2,冯明智3作
5、者单位:1河南大学第一附属医院皮肤科,河南 开封475001;2深圳市龙华区人民医院皮肤科,广东 深圳518000;3苏州市第五人民医院皮肤科,江苏 苏州215100通信作者:聂磊,女,主任医师,研究方向为面部痤疮的综合治疗,Email:基金项目:开封市科技发展计划项目(1903103)摘要:目的 观察超脉冲二氧化碳点阵激光联合黄金微针射频治疗面部痤疮凹陷性瘢痕的疗效。方法 选择2019年3月至2021年3月在河南大学第一附属医院皮肤科门诊按就诊顺序将符合诊断标准的面部痤疮凹陷性瘢痕病人70例,分为观察组和对照组,每组35例。观察组采用超脉冲二氧化碳点阵激光和黄金微针射频交替治疗,首次使用超脉
6、冲二氧化碳点阵激光,间隔2周后用黄金微针射频。对照组采用黄金微针射频单独治疗,间隔4周。结果 两组痤疮瘢痕临床评分量表(ECCA)权重评分治疗前观察组(52.2920.48)分,对照组(51.4326.58)分,组间比较,差异无统计学意义(Z=0.49,P=0.623);治疗后观察组降至(23.2915.43)分,治疗前后比较差异有统计学意义(Z=4.73,P0.001);对照组降至(37.1419.03)分,治疗前后比较差异有统计学意义(Z=3.48,P0.001),治疗后两组比较,差异有统计学意义(Z=3.16,P=0.002)。观察组治疗总有效率为91.43%,对照组为74.29%,组间
7、比较,差异有统计学意义(2=4.57,P=0.031)。观察组术后红肿持续、愈合及休工时间低于对照组,差异有统计学意义(P0.001)。结论 超脉冲二氧化碳点阵激光与黄金微针射频联合应用能够显著改善临床疗效,还可以减轻病人术后不良反应,两者联合应用,安全、有效,值得临床推广。关键词:寻常痤疮;瘢痕瘤性痤疮;脉冲射频术;二氧化碳点阵激光;黄金微针;痤疮瘢痕Efficacy of an ultra-pulsed carbon dioxide fractional laser combined with gold microneedle radiofrequency in the treatment
8、 of facial acne depression scarsLI Xiaoyan1,NIE Lei1,GUO Wei1,CHENG Shaohang2,FENG Mingzhi3Author Affiliation:1Department of Dermatology,The First Affiliated Hospital of Henan University,Kaifeng,Henan 475001,China;2Department of Dermatology,The Peoples Hospital of Longhua,Shenzhen,Guangdong 518000,C
9、hina;3Department of Dermatology,The Fifth Peoples Hospital of Suzhou,Suzhou,Jiangsu 215100,China引用本文:李小燕,聂磊,郭伟,等.超脉冲二氧化碳点阵激光联合黄金微针射频治疗面部痤疮凹陷性瘢痕的疗效观察 J.安徽医药,2023,27(2):324-327.DOI:10.3969/j.issn.1009-6469.2023.02.025.临床医学324安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2023 Feb,27(2)Abstract:Objec
10、tive To investigate the efficacy of an ultra-pulsed carbon dioxide fractional laser combined with gold microneedle radiofrequency in the treatment of facial acne depression scars.Methods A total of 70 patients with depressed facial acne scars who met the diagnostic criteria in the outpatient clinic
11、of the Department of Dermatology of the First Affiliated Hospital of Henan University in the order of consultation from March 2019 to March 2021 were selected and divided into an observation group and a control group,with 35 patients in each group.The observation group was treated with alternating u
12、ltra-pulsed CO2 laser and gold microneedle radiofrequency,with the first use of ultra-pulsed CO2 fractional laser and 2-week interval followed by gold microneedle radiofrequency.The control group was treated with gold microneedle radiofrequency alone with an interval of 4 weeks.Results Before treatm
13、ent,the weight scores of the acne scar clinical scale(ECCA)in the observation group(52.2920.48)and the control group(51.4326.58)were not statistically significant(Z=0.49,P=0.623).After treatment,the observation group decreased to(23.2915.43)points,and the difference was statistically significant whe
14、n comparing before and after treatment(Z=4.73,P0.001).The control group decreased to(37.1419.03)points,and the difference was statistically significant when comparing before and after treatment(Z=3.48,P0.001).The difference was statistically significant when comparing between the two groups after tr
15、eatment(Z=3.16,P=0.002).The overall effective rate was 91.43%in the observation group and 74.29%in the control group,with statistically significant differences between groups(2=4.57,P=0.031).The duration of redness and swelling,healing and rest time after surgery were lower in the observation group
16、than in the control group,and the difference was statistically significant(P0.001)。本研究符合 世界医学协会赫尔辛基宣言 相关要求。1.2治疗方法观察组首先清洁面部,厚厚地在治疗区涂抹一层复方利多卡因乳膏(同方药业集团有限公司)6090 min,成功麻醉后,再次清洁消毒面部,调节超脉冲二氧化碳点阵激光能量、密度(采用能量3040 mj/cm2,能量密度1.56%)对轻重不同的面部凹陷性瘢痕进行治疗,重复 1次治疗。治疗 2周后用对照组的方法进行黄金微针射频治疗,两侧颊部及鼻部使用1.5 mm,能量为4 level;额部、双侧下颌部、颞部及双侧眼周皮肤组织使用0.50.8 mm,能量为3 level。治疗时手柄和皮肤完全接触并保持垂直,将手背适当施加压力,紧贴皮肤,减少皮肤损伤,治疗头在上下左右四个方向各重叠20%进行操作,重复2遍。二者交替治疗4次为一个疗程;对照组:采用黄金微针射频单独治疗,同观察组黄金微针射频操作方法,每次治疗间隔时间4周,一个疗程为连续4次。4次结束半年后随访。治疗结束后冰敷治疗区,