1、天道酬勤分析腹膜外腹腔镜疝气修补术和传统疝气修补术治疗腹股沟疝的疗效差异王雨辰 黄志敏 目的 研究腹膜外腹腔镜疝气修补术和传统疝修补术对腹股沟疝患者的临床效果差异。方法 方便选取该院于2023年3月2023年4月收治的80例腹股沟疝病患者作为研究对象,按照入院时间将患者分为观察组和对照组各40例。对照组患者接受传统疝修补术,观察组进行传统疝修补术,比照两组患者手术时间、住院时间、开始下床活动时间,检测并比照两组患者在术前1 d和术后1、3、5 d血清疼痛相关指标血清SP、NGF、NE和NPY的差异。结果 观察组手术时间49.639.24min、住院时间4.951.59d均短于对照组,开始下床活
2、动时间15.176.92h时间早于对照组的下床活动时间29.836.71h,两组间差异有统计学意义P0.05,观察组的血清疼痛相关指标血清SP、NGF、NE和NPY水平均明显低于对照组,差异有统计学意义P0.05。结论 腹股沟疝患者行腹膜外腹腔镜疝气修补术较传统疝修补术缩短了手术时间、住院时间,患者更早下床活动,康复效果和生活质量有所提高。关键词 腹股沟;疝腹腔镜; 疝气修补术中图分类号 R656 文献标识码 A 文章编号 1674-0742202306a-0092-03Analysis of the Difference in Efficacy between Extraperitoneal
3、 Laparoscopic Hernia Repair and Traditional Hernia Repair for Inguinal HerniaWANG Yu-chen, HUANG Zhi-minDepartment of Surgery, North Hospital of Fujian Provincial HospitalFujian Geriatric Hospital, Fuzhou, Fujian Province, 350001 ChinaAbstract Objective To study the clinical effect of extraperitonea
4、l laparoscopic hernia repair and traditional hernia repair on patients with inguinal hernia. Methods A total of 80 patients with inguinal hernia received from the hospital from March 2023 to April 2023 were convenient selected as the research subjects, and the patients were divided into observation
5、group and control group 40 cases according to the admission time. Patients in the control group underwent traditional hernia repair, and observation group underwent traditional hernia repair. The operation time, length of hospital stay, and time to start getting out of bed were compared between the
6、two groups, differences of serum SP, NGF, NE and NPY in serum-related indexes on 1, 3, 5 d. Results The operation time 49.639.24min and hospital stay 4.951.59d in the observation group were shorter than those in the control group. The time to start getting out of bed 15.176.92d was earlier than that
7、 in the control group 29.836.71d, the difference between the two groups was statistically significantP0.05. The serum pain-related indicators in the observation group were significantly lower than those in the control group, and the differences were statistically significant P0.05,具有可比性。该研究经过该院伦理委员会
8、批准,且所有患者均签署知情同意书。1.2 方法1.2.1 手术方法 对照组患者采用传统疝修补术,具体方法是以硬膜外麻醉处理,对疝囊予以高位结扎,修补患者腹股沟管处的受损管壁3。观察组采用腹腔镜下腹股沟疝修补术治疗,对患者全身麻醉,体位取头低脚高位、健侧卧位。在患者脐部下缘做弧形切口,长度为2 cm,达腹直肌前鞘。将患者腹直肌向患侧方向牵拉,通过手指别离腹直肌,进到腹膜前间隙。在脐下2 cm水平腹直肌外侧缘穿刺放置2个5 mm的Trocar,由脐下皮肤切口将10 mm Trocar置入,建立气腹后别离耻骨后间隙及腹股沟后间隙。腹腔镜下对患者实施疝囊游离,通过套扎线实行疝囊的结扎工作。保持补片弯曲
9、,以套管鞘内放入,确保上缘超过腹横机弓状下缘,下界遮盖股管内口。拔出套管后,解除气腹,将腹膜自然恢复并压迫固定补片4。1.2.2 检测指标和方法 一般指标:将两组患者的手术时间、住院时间、开始下床活动时间进行比拟。利用 ELISA检测SP、NGF、NE和NPY水平变化:两组患者术前1 d及术后1、3、5 d均清晨空腹状态下抽取肘静脉血10 mL于离心管里盖好,竖直放置在离心试管架上转入低温室以离心机4 000r/min、离心5 min后别离出上清液,将抗体用碳酸被缓冲液进行稀释到适宜浓度,然后倒入0.1 mL至反响孔中,4孵育过夜5。然后,用PBS冲洗3次,2 min/次,随后参加待测样品,在
10、室温下进行反响。1 h后,继续用PBS冲洗3次,2 min/次。再参加新鲜稀释的酶标抗体,在室温下孵育1 h后洗涤。然后将0.1 mL TMB底物溶液参加到每个反响孔中,充分反响后参加0.05 mL的2 mol/L硫酸进行显色,在酶标仪中进行显色测定,计算出OD值6。所有操作均严格按照说明书进行。1.3 统计方法该次研究实验数据均采用SPSS 19.0统计学软件进行统计分析,计量资料用xs表示,进行t检验,P0.05为差异有统计学意义。2 结果2.1 手术时间、住院时间及下床活动时间开始下床活动时间观察组患者手术时间、住院时间明显短于对照组,且住院时间、下床活动时间开始下床活动时间较对照组早,
11、差异有统计学意义P0.05,而术后1、3、5 d ,观察组患者的血清疼痛相关指标均低于对照组患者,差异有统计学意义P0.05,见表2。3 讨论腹股沟疝疾病是由于腹压增高导致的以一种常见病,传统的腹股沟疝修补术以结扎为主要治疗方式,在术中对解剖层次不同的结构缝合在一起,容易使得张力提升,创伤性较大7。人们追求更理想的治疗手段,近年腹膜外腹腔镜疝气修补术已逐渐开展成熟,弥补了传统疝修补术不能满足人体解剖生理特点的缺乏,受到了医生和患者歡迎。腹膜外腹腔镜疝气修补术的具体操作方法是从脐下缘切口到腹股沟疝发生的起始位置,利用网片增强修复该位置,从而到达治疗的效果。该治疗方法成功与否的关键在于必须建立良好的腹膜外间隙,并将网片放置固定好。腹膜外腹腔镜疝气修补术避开了进入腹腔的操作,腹膜外区修补也无需通过钉固定,创伤性明