1、Designation:D845622Standard Test Method forDetermination of Nitrosamines in Water by LiquidChromatography Tandem Mass Spectrometry(LC-MS/MS)1This standard is issued under the fixed designation D8456;the number immediately following the designation indicates the year oforiginal adoption or,in the cas
2、e of revision,the year of last revision.A number in parentheses indicates the year of last reapproval.Asuperscript epsilon()indicates an editorial change since the last revision or reapproval.1.Scope1.1 This test method covers the liquid chromatographytandem mass spectrometry(LC-MS/MS)detection and
3、quan-titation of N-nitrosamines after direct injection.It has beenvalidated for groundwater,surface water,wastewater influents,and wastewater effluents.This test method is not limited tothese aqueous matrices;however,the applicability of this testmethod to other aqueous matrices must be demonstrated
4、.1.2 This test method is applicable to nitrosamines that canbe chromatographed and detected using a mass spectrometryprocedure.Table 1 lists the compounds that have been vali-dated for this test method.This test method is not limited to thecompounds listed in Table 1;however,the applicability of the
5、test method to other compounds must be demonstrated.1.3 Analyte concentrations from 0.05 g/L up to approxi-mately 5 g/L may be determined without dilution of thesample.Analytes with insufficient sensitivity will not bedetected,but they can be measured with acceptable accuracyand precision when prese
6、nt in sufficient amounts.In addition,newer instruments,or instruments of improved sensitivity maybe used to lower detection limits.1.4 Analytes that are not separated chromatographically,butthat have different mass spectra and noninterfering quantitationions,can be identified and measured in the sam
7、e calibrationmixture or water sample.Analytes that have very similarproduct ions cannot be individually identified and measured inthe same calibration mixture or water sample unless they havedifferent retention times.1.5 It is the responsibility of the user to ensure the validityof this test method
8、for untested matrices.1.6 This test method is restricted to use by or under thesupervision of analysts experienced in the use of a liquidchromatograph with tandem mass spectrometry(LC-MS/MS).1.7 Depending on data usage,you may modify this testmethod but limit to modifications that improve performanc
9、ewhile still meeting method quality acceptance criteria.Short-ening the chromatographic run simply to save time is notallowed.Use Practice E2935 or similar statistical tests toconfirm that modifications produce equivalent results on non-interfering samples.In addition,use Guide E2857 or equivalentst
10、atistics to re-validate the modified test.1.8 The values stated in SI units are to be regarded asstandard.No other units of measurement are included in thisstandard.1.9 This standard does not purport to address all of thesafety concerns,if any,associated with its use.It is theresponsibility of the u
11、ser of this standard to establish appro-priate safety,health,and environmental practices and deter-mine the applicability of regulatory limitations prior to use.1.10 This international standard was developed in accor-dance with internationally recognized principles on standard-ization established in
12、 the Decision on Principles for theDevelopment of International Standards,Guides and Recom-mendations issued by the World Trade Organization TechnicalBarriers to Trade(TBT)Committee.2.Referenced Documents2.1 ASTM Standards:2D1129 Terminology Relating to WaterD1193 Specification for Reagent WaterD277
13、7 Practice for Determination of Precision and Bias ofApplicable Test Methods of Committee D19 on WaterD3370 Practices for Sampling Water from Flowing ProcessStreamsD4448 Guide for Sampling Ground-Water Monitoring WellsD6089 Guide for Documenting a Groundwater SamplingEventD6538 Guide for Sampling Wa
14、stewater With AutomaticSamplersD6759 Practice for Sampling Liquids Using Grab and Dis-crete Depth SamplersE2857 Guide for Validating Analytical Methods1This test method is under the jurisdiction of ASTM Committee D19 on Waterand is the direct responsibility of Subcommittee D19.06 on Methods forAnaly
15、sis forOrganic Substances in Water.Current edition approved May 1,2022.Published July 2022.DOI:10.1520/D8456-22.2For referenced ASTM standards,visit the ASTM website,www.astm.org,orcontact ASTM Customer Service at serviceastm.org.For Annual Book of ASTMStandards volume information,refer to the stand
16、ards Document Summary page onthe ASTM website.Copyright ASTM International,100 Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959.United StatesThis international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for theDevelopment of International Standards,Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade(TBT)Committee.1E2935 Practice for Evaluating E