1、Designation:C 1476 06Standard Test Method forAnalysis of Urine for Technetium-99 by Inductively CoupledPlasma-Mass Spectrometry1This standard is issued under the fixed designation C 1476;the number immediately following the designation indicates the year oforiginal adoption or,in the case of revisio
2、n,the year of last revision.A number in parentheses indicates the year of last reapproval.Asuperscript epsilon(e)indicates an editorial change since the last revision or reapproval.1.Scope1.1 This test method covers the determination of the con-centration of technetium-99 in urine using inductively
3、coupledplasma-mass spectrometry(ICP-MS).This test method can beused to support uranium enrichment and reclamation facilitybioassay programs.1.2 The minimum detectable concentration for this testmethod,using a quadrupole ICP-MS,is approximately 1.0ng/L(0.62 Bq/L).1.3 This standard does not purport to
4、 address all of thesafety concerns,if any,associated with its use.It is theresponsibility of the user of this standard to establish appro-priate safety and health practices and determine the applica-bility of regulatory limitations prior to use.2.Referenced Documents2.1 ASTM Standards:2C 1009 Guide
5、for Establishing a Quality Assurance Pro-gram for Analytical Chemistry Laboratories Within theNuclear IndustryC 1068 Guide for Qualification of Measurement Methodsby a Laboratory Within the Nuclear IndustryC 1128 Guide for Preparation of Working Reference Mate-rials for Use in the Analysis of Nuclea
6、r Fuel CycleMaterialsC 1156 Guide for Establishing Calibration for a Measure-ment Method Used to Analyze Nuclear Fuel Cycle Mate-rialsC 1210 Guide for Establishing a Measurement SystemQuality Control Program for Analytical Chemistry Labo-ratories Within the Nuclear IndustryC 1297 Guide for Qualifica
7、tion of Laboratory Analysts forthe Analysis of Nuclear Fuel Cycle MaterialsD 1193 Specification for Reagent Water2.2Other Standards:ANSI N13.20 Radiological Measurement Quality3Code of Federal Regulations,Title 10,835.4024HPS N13.30 Performance Criteria for Radiobioassay53.Terminology3.1 Definitions
8、:3.1.1 instrument check standard,nstandard solutionsevaluated at given intervals during batch analysis to evaluateinstrument stability during analysis.3.1.2 internal reference standard,nstandard solutions,containing an element with similar chemical properties to theanalyte of interest,added to each
9、calibration standard,checkstandard,and sample for the purpose of monitoring andcorrecting for fluctuations in matrix,instrument drift,nebulizerand sample orifice blockages,and aerosol transport effects.3.1.3 isobar,nany nuclide that has the same atomic massnumber as another atom,but a different atom
10、ic number.3.2 Acronyms:Acronyms:3.2.1 ICP-MS,ninductively coupled plasma-mass spec-trometry.3.2.2 LOD,nlimit of detection.3.2.3 LCS,nlaboratory control standard.3.2.4 MDC,nminimum detectable concentration.3.2.5%RSD,npercent relative standard deviation(1 stan-dard deviation/Mean)*100.3.2.6%Bias,n(mea
11、n true value)/true value)*100.4.Summary of Test Method4.1 A urine sample is digested in the presence of hydrogenperoxide to decompose the organic matrix.The pertechnetateion is selectively separated from ruthenium,actinides,alkali,and alkaline earth metals in the sample matrix using anionexchange ch
12、romatography.The99Tc is eluted with warmed 3.01This test method is under the jurisdiction ofASTM Committee C26 on NuclearFuel Cycle and is the direct responsibility of Subcommittee C26.05 on Methods ofTest.Current edition approved Jan.1,2006.Published January 2006.Originallyapproved in 2000.Last pre
13、vious edition approved in 2000 as C 1476 00.2For referenced ASTM standards,visit the ASTM website,www.astm.org,orcontact ASTM Customer Service at serviceastm.org.For Annual Book of ASTMStandards volume information,refer to the standards Document Summary page onthe ASTM website.3Available from Americ
14、an National Standards Institute(ANSI),25 W.43rd St.,4th Floor,New York,NY 10036.4Available from U.S.Government Printing Office Superintendent of Documents,732 N.Capitol St.,NW,Mail Stop:SDE,Washington,DC 20401.5Health Physics Society,“Performance Criteria for Radiobioassay,”HPSN13.30,McLean,VA,1996.
15、1Copyright ASTM International,100 Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959,United States.Copyright by ASTM Intl(all rights reserved);Thu Apr 16 09:22:04 EDT 2009Downloaded/printed byLaurentian University pursuant to License Agreement.No further reproductions authorized.M nitric
16、acid.The99Tc isotope is analyzed by ICP-MS using asuitable internal standard such as115In.6The chemical recoveryis determined by the sample,sample spike method.Recoveriesobtained from submitted samples over a one-year periodaveraged 90%.5.Significance and Use5.1 Code of Federal Regulations,Title 10,835.402 statesthat radiological workers who are likely to receive 100 mremfrom intakes are required to be monitored for exposure.For theindirect bioassay for radiological workers exposed to nuclearmat