1、世界中西医结合杂志 2023 年第 18 卷第 1 期World Journal of Integrated Traditional and Western Medicine2023，Vol.18，No.1临床研究DOI:10 13935/j cnki sjzx 230122基金项目:北京中医药大学东方医院“1166”人才工程中青年专家项目(040204001001003025);北京市丰台区卫生系统科学研究项目(2014 09)作者单位:1 北京中医药大学，北京 100029;2 北京中医药大学东方医院乳腺科，北京 100078通信作者:赵立娜，Email:linalucky2010126
2、com乳痛愈药膜治疗肝郁气滞型乳腺增生病患者的疗效观察舒国发1祝东升2赵立娜2翟臻2钟馨2李桃花2李巍2李以良2【摘要】目的研究乳痛愈药膜对肝郁气滞型乳腺增生病的疗效及安全性。方法选取 2015 年 5 月2016 年 7 月期间北京中医药大学东方医院乳腺科门诊收治的肝郁气滞型乳腺增生病患者 100 例，按 1 1 的比例随机分为治疗组和对照组。100 例入组病例中，共收集完整数据病例 89 例，对照组 46 例，治疗组 43 例，剔除 11例。对照组采用荞麦面粉治疗，即在患者双侧乳房上敷荞麦面粉糊后，在面糊表面覆盖煅石膏糊;治疗组采用等量乳痛愈药膜治疗:在患者双侧乳房上敷乳痛愈药膜后，同样在
3、药膜表面覆盖煅石膏糊;两组患者治疗时间均为20 min/次，隔天 1 次，每个月经周期治疗不少于 10 次，治疗周期为 3 个月经周期，经期不用药，治疗结束后随访 1个月经周期。观察两组患者治疗前后乳房疼痛、乳房肿块等指标的变化。结果治疗 1 周期、2 周期、3 周期后及随访期两组患者乳房疼痛积分均较治疗前降低，差异有统计学意义(P 0 01);且治疗组乳房疼痛程度积分下降程度优于对照组，差异有统计学意义(P 0 01)。治疗 1 周期、2 周期、3 周期后及随访期两组患者乳腺相关症状体征(疼痛、肿块)积分均较治疗前降低，差异有统计学意义(P 0 01);且治疗组乳腺相关症状体征(疼痛、肿块)
4、积分下降程度优于对照组，差异有统计学意义(P 0 01)。治疗组治疗 3 周期后总有效率 76 74%(33/43)、随访期总有效率 79 07%(34/43)均较对照组治疗 3 周期后 32 61%(15/46)、随访期 32 61%(15/46)升高，差异有统计学意义(P 0 01)。治疗 1 周期、2 周期、3 周期后及随访期两组患者中医证候综合疗效总积分均较治疗前降低，差异有统计学意义(P 0 01);且治疗组中医证候综合疗效总积分下降程度优于对照组，差异有统计学意义(P 0 01)。治疗 3 周期后治疗组中医证候综合疗效总有效率 76 74%(33/43)、随访期 79 07%(34
5、/43)均较对照组 26 09%(12/46)、随访期 28 26%(13/46)升高，差异有统计学意义(P 0 01)。两组患者治疗期间均未发生皮肤刺激、过敏相关的不良反应。结论乳痛愈药膜治疗肝郁气滞型乳腺增生病能明显减轻乳房疼痛等症状，能够缩小肿块，疗效确切且安全，无皮肤刺激不良反应。【关键词】乳腺增生病;乳痛愈药膜;中药外治【中图分类号】655 8【文献标识码】AClinical Study of utongyu Medicine Membrane on Mammary Hyperplasia of LiverStagnation and Qi StagnationSHU Guo fa1
6、，ZHU Dong sheng2，ZHAO Li na2，ZHAI Zhen2，ZHONG Xin2，LI Tao hua2，LI Wei2，LI Yi liang2(1 Beijing University of traditional Chinese medicine，Beijing 100029;2 Department of mammary gland，Oriental Hospi-tal，Beijing University of traditional Chinese medicine，Beijing 100078)【Abstract】ObjectiveTo study the e
7、fficacy and safety of utongyu Medicine Membrane in the treatment of mam-mary hyperplasia with liver stagnation and qi stagnation MethodsA total of 100 patients with liver stagnation and qistagnation type mammary hyperplasia admitted to the department of mammary gland of Oriental Hospital of Beijing
8、Univer-sity of traditional Chinese Medicine from May 2015 to July 2016 were selected and randomly divided into treatment groupand control group according to a ratio of 1 1 Among the 100 included cases，a total of 89 cases with complete data werecollected，including 46 cases in the control group，43 cas
9、es in the treatment group and 11 cases excluded The control groupwas treated with buckwheat flour:after applying buckwheat flour paste on both breasts of the patient，the surface of the bat-ter was covered with calcined gypsum paste;The treatment group was treated with the same amount of utongyu Medi
10、cineMembrane:after applying the utongyu Medicine Membrane on both breasts of the patient，the surface of the membrane wasalso covered with calcined plaster The treatment duration of the two groups was 20 minutes，once every other day，no less231世界中西医结合杂志 2023 年第 18 卷第 1 期World Journal of Integrated Tra
11、ditional and Western Medicine2023，Vol.18，No.1than 10 times per menstrual cycle The treatment cycle was 3 menstrual cycles，no medication was used during menstrualperiod，and the follow up period was 1 menstrual cycle after the end of treatment The changes of breast pain，breastlumps and other indexes w
12、ere observed before and after treatment esultsAfter 1，2 and 3 cycles of treatment and in thefollow up period，the breast pain score of both groups was significantly decreased compared with that before treatment(P0 01)，and the reduction degree of breast pain score of the treatment group was significan
13、tly better than that of the con-trol group(P 0 01)In addition，after 1，2，3 cycles of treatment and at the follow up period，the scores of mammarygland related symptoms and signs(pain，mass)in both groups were significantly reduced compared with those before treat-ment(P 0 01)，and the scores of mammary
14、gland related symptoms and signs(pain，mass)in the treatment group weresignificantly reduced than those in the control group(P 0 01)After 3 cycles of treatment，the total effective rate of thetreatment group was 76 74%(33/43)，and the total effective rate of the follow up period was 79 07%(34/43)，which
15、were significantly higher than that of the control group 32 61%(15/46)and the follow up period 32 61%(15/4)，P0 01 After 1，2 and 3 cycles of treatment and in the follow up period，the total score of comprehensive efficacy ofTCM syndrome in two groups was significantly decreased compared with that befo
16、re treatment(P 0 01)，and the decreasedegree of total score of comprehensive efficacy of TCM syndrome in the treatment group was significantly better than that inthe control group(P 0 01)The total effective rate of the comprehensive effect of TCM syndrome in the treatment groupafter 3 cycles was 76 74%(33/43)，and that in the follow up period was 79 07%(34/43)，both of which were signifi-cantly higher than that in the control group after 3 cycles 26 09%(12/46)and that in the follow up period 28 26%