1、844 26 AUGUST 2016 VOL 353 ISSUE 6302sciencemag.org SCIENCE26 AUGUST 2016 VOLUME 353 ISSUE 6302CONTENTS887A receptor for retinol NEWSIN BRIEF850 News at a glanceIN DEPTH 852 ANTHROPOCENE PINNED TO POSTWAR PERIODGeologists vote to seek a“golden spike,”but push for formal acceptance faces skepticism B
2、y P.Voosen853 NASA FLIES INTO NAMIBIAS CLOUD LABORATORYCommingling smoke and fog pose thorny climate puzzles By E.Hand855 CHOLESTEROL SCREENING FOR KIDS SPARKS DEBATE(AGAIN)Evidence for universal testing is insufficient,task force says By J.Couzin-Frankel856 RESEARCH WATCHDOGS NEW LEADER FACES STAFF
3、 REVOLTORI head tries to chart future course,but staff warn of“tensions and conflict”in letters to her superiors By J.KaiserINSIGHTSPERSPECTIVES 864 HASSLES VERSUS PRICESHow can subsidized health products best target those who value them?By B.A.Olken RESEARCH ARTICLE P.889857 THE EXOPLANET NEXT DOOR
4、Earth-like planet found 4 light-years away around Proxima Centauri,the closest star By D.CleryFEATURES 858 THE CARBON ACCOUNTANTRichard Heede pins much of the responsibility for climate change on just 90 companies.Others say thats a cop-out By D.Starr 862 EUROPES NEW HEPATITIS PROBLEMMany get infect
5、ed with hepatitis E,and a few get very sick.How can the virus be stopped?By K.Kupferschmidt88866 BUILDING MOLECULAR COMPLEXITY FROM SCRATCHThe Pauson-Khand cycloaddition reaction builds the tetracyclic core of(+)-ryanodol By X.Verdaguer REPORT P.912867 DO YOU SPEAK LION?To be effective,conservation
6、decisions must be transparent and based on diverse views By W.M.Adams869“WEATHER BOMB”INDUCED SEISMIC SIGNALSSeismic waves generated by intense storms can reveal details of Earths interior By P.Gerstoft and P.D.Bromirski REPORT P.919870 PROLINE HYDROXYLATIONLINKED TO AKT ACTIVATIONOxygen-sensing enz
7、ymes regulate the Akt kinase By M.Voulgarelis and P.N.Tsichlis REPORT P.929872 A PATH TOWARD UNDERSTANDINGNEURODEGENERATIONA focus on cell biology may accelerate progress in disease prevention and cures By K.S.Kosik et al.POLICY FORUM 874 ACHIEVING GLOBAL TARGETS FOR ANTIMICROBIAL RESISTANCEThe UN s
8、hould promote targets,funding,and governance By R.Laxminarayan et al.BOOKS ET AL.876 THE FUTURE OF THREE-DIMENSIONAL THINKINGA new holographic platform holds promise for enhancing education,research,and collaboration By M.A.Hoffman877 NAVIGATING TODAYS JOB MARKETA step-by-step guide offers practical
9、 science career advice By T.A.Dellibovi-Ragheb877 BUILDING STAR TREKBy B.Jasny853Published by AAAS on September 3,2016http:/science.sciencemag.org/Downloaded from 26 AUGUST 2016 VOL 353 ISSUE 6302 845SCIENCE sciencemag.org885Wiring up colloidal devices922Forecasting for complex ecosystemsScience Sta
10、ff.846AAAS News&Notes.880New Products.937Science Careers.938DEPARTMENTS849 EDITORIAL Benefits of steady growthBy Jeremy Berg954 WORKING LIFEAdaptability in life and workBy Amit Kumar887 STRUCTURAL BIOLOGYStructure of the STRA6 receptor for retinol uptake Y.Chen et al.RESEARCH ARTICLE SUMMARY;FOR FUL
11、L TEXT:dx.doi.org/10.1126/science.aad8266888 ACTINIDE CHEMISTRYCharacterization of berkelium(III)dipicolinate and borate compounds in solution and the solid state M.A.Silver et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf3762889 HEALTH ECONOMICSTargeting health subsidies
12、through a nonprice mechanism:A randomized controlled trial in Kenya P.Dupas et al.PERSPECTIVE P.864STRUCTURAL BIOLOGY895 Structure of a yeast catalytic step I spliceosome at 3.4 resolution R.Wan et al.904 Structure of a yeast activated spliceosome at 3.5 resolution C.Yan et al.RESEARCH ARTICLE BY R.
13、RAUHUT ET AL.10.1126/science.aag1906REPORTS 912 ORGANIC SYNTHESISA 15-step synthesis of(+)-ryanodol K.V.Chuang et al.PERSPECTIVE P.866916 ULTRAFAST DYNAMICSAttosecond dynamical Franz-Keldysh effect in polycrystalline diamond M.Lucchini et al.919 GEOPHYSICSTeleseismic S wave microseisms K.Nishida and
14、 R.Takagi PERSPECTIVE P.869922 TIME SERIES ANALYSISInformation leverage in interconnected ecosystems:Overcoming the curse of dimensionality H.Ye and G.Sugihara925 SINGLE-CELL GENOMICSDiv-Seq:Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons N.Habib et al.929 SIGNAL TRANSDUCTIONpV
15、HL suppresses kinase activity of Akt in a proline-hydroxylationdependent manner J.Guo et al.PERSPECTIVE P.870933 VIROLOGYDiscovery of a proteinaceous cellular receptor for a norovirus R.C.Orchard et al.RESEARCH ARTICLE BY K.ETTAYEBI ET AL.10.1126/science.aaf5211ON THE COVERA low-pressure system swir
16、ls off the coast of Greenland.A seismic array in Japan is now being used to detect seismic waves generated by ocean swell from a more powerful system known as a“weather bomb”in North Atlantic waters.The ability to collect precise seismic source locations of distant storms may provide a new approach for exploring Earths interior.See pages 869 and 919.Photo:Jacques Descloitres,MODIS Rapid Response Team,NASA/GSFCSCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last week in December,b