1、CREDITS:(FROM TOP TO BOTTOM)A.KITTERMAN/SCIENCE;JESSE S.JONES/UNIVERSITY OF FLORIDA;DAVIDE BONAZZI/SALZMANART6 APRIL 2018 VOL 360 ISSUE 6384 5SCIENCE sciencemag.org6 APRIL 2018 VOLUME 360 ISSUE 6384CONTENTS33&49Repairing a leaky membraneNEWSIN BRIEF10 News at a glanceIN DEPTH 12 IN ITS SECOND YEAR,M
2、ARCH FOR SCIENCE GROWS UPThis years event,set for 14 April,is only one element in a global pro-science movement By J.Mervis13 UNIVERSITY IS QUICK TO DISCLOSE MISCONDUCT The Ohio State University wins plaudits for unusually rapid transparency By A.McCook14 HUMANE STUDIES OF OCTOPUSES GET A BOOST By i
3、dentifying effective anesthetics,findings aid compliance with regulations By D.Staaf PODCAST16 ROCKY START FOR CHINAS JAMES WATSON CENTERA new center named for the Nobel laureate faces funding and mission challenges By D.NormileINSIGHTSLETTERS 26 NEXTGEN VOICES:A POSTDOCS PURPOSEPERSPECTIVES 28 MICR
4、OPLASTICS RESEARCHFROM SINK TO SOURCEMicroplastics are ubiquitous not just in the ocean but also on land and in freshwater systems By C.M.RochmanXXX30 SUPPORTING RECOVERY FROM BRAIN INJURYA window of therapeutic opportunity could widen beyond the initial phase of brain injury By S.Rumpel RESEARCH AR
5、TICLE P.5031 LATTICES FOR FRACTIONAL CHERN INSULATORSTopological order beyond Landau levels is seen in encapsulated bilayer graphene By C.Repellin and N.Regnault REPORT P.6233 ESCRTS OFFER REPAIR SERVICEA cellular membrane remodeling machinery repairs damaged organelles By M.G.Gutierrez and J.G.Carl
6、ton RESEARCH ARTICLE P.4934 UP CLOSE WITH HERPESVIRUSESTwo high-resolution structures reveal how 3000 proteins are arranged in the herpes simplex virus capsid By E.E.Heldwein RESEARCH ARTICLES PP.47&4836 LRRK2 KINASE IN PARKINSONS DISEASEDefects in vesicular trafficking and immune responses are foun
7、d in Parkinsons disease By D.R.Alessi and E.SammlerPOLICY FORUM 38 TESTING INTERNATIONALEDUCATION ASSESSMENTSRankings get headlines,but often mislead By J.D.Singer and H.I.Braun38X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X
8、 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X
9、X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X
10、 X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X1817 NIH LOOKS TO PUNISH REVIEWERS WHO VIOLATE CONFIDENTIALITYAgency re-reviewed dozens of funding proposals after officials discovered a violation of the r
11、ules By J.BrainardFEATURES 18 A DELICATE BALANCERoutinely giving antibiotics to premature babies may do more harm than good By M.Broadfoot22 EDGE OF EXTINCTIONIndias paleontologists are struggling to save fossil sitesand their own discipline By S.Kumar24 A one-man fossil rescue missionBy S.KumarDA_0
12、406TOC.indd 54/3/18 9:15 PMPublished by AAASon April 8,2018 http:/science.sciencemag.org/Downloaded from CREDITS(FROM TOP TO BOTTOM)K.CHEN ET AL.;ROBERT NEUBECKER6 APRIL 2018 VOL 360 ISSUE 6384 7SCIENCE sciencemag.orgCONTENTS71Strained ring synthesizer6 APRIL 2018 VOLUME 360 ISSUE 6384RESEARCHIN BRI
13、EF 44 From Science and other journalsRESEARCH ARTICLES STRUCTURAL BIOLOGY47 Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes X.Dai and Z.H.Zhou RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aao729848 Cryo-EM structure of a herpesvirus caps
14、id at 3.1 S.Yuan et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aao7283 PERSPECTIVE P.3449 CELL BIOLOGYTriggered recruitment of ESCRT machinery promotes endolysosomal repair M.L.Skowyra et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aar5078 PERSPECTI
15、VE P.3350 NEUROSCIENCECRMP2-binding compound,edonerpic maleate,accelerates motor function recovery from brain damage H.Abe et al.PERSPECTIVE P.3058 NITROGEN CYCLEConvergent evidence for widespread rock nitrogen sources in Earths surface environment B.Z.Houlton et al.REPORTS 62 TOPOLOGICAL MATTERObse
16、rvation of fractional Chern insulators in a van der Waals heterostructure E.M.Spanton et al.PERSPECTIVE P.3167 SOLAR CELLSLight-induced lattice expansion leads to high-efficiency perovskite solar cells H.Tsai et al.71 BIOCATALYSISEnzymatic construction of highly strained carbocycles K.Chen et al.75 ORGANIC CHEMISTRYModular radical cross-coupling with sulfones enables access to sp3-rich(fluoro)alkylated scaffolds R.R.Merchant et al.81 NEURODEVELOPMENTEarly emergence of cortical interneuron divers