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6、91-1695.（收稿日期：2022-04-23，修回日期：2022-05-22）两种超促排卵方案对卵巢正常反应病人体外受精-胚胎移植/卵胞浆内单精子注射的效果比较吕小晶1，冯文娟2，王凯2，张迎春2作者单位：1潍坊医学院临床医学院，山东 潍坊261053；2济南市中心医院生殖医学科，山东 济南250013通信作者：张迎春，女，主任医师，硕士生导师，研究方向为生殖内分泌，Email：摘要：目的 比较早卵泡期长效长方案与拮抗剂方案在助孕治疗的卵巢正常反应病人中的应用效果。方法 回顾性分析2019年1月至2021年12月于济南市中心医院生殖医学中心行体外受精-胚胎移植（IVF-ET）/卵胞浆内单精
7、子注射（ICSI）助孕治疗的卵巢正常反应病人的临床资料。该研究共计587个周期，包括365个早卵泡期长效长周期（长效长方案组）和222个拮抗剂周期（拮抗剂方案组）。比较两组病人的一般资料、促排卵及胚胎情况、新鲜周期胚胎移植情况、临床结局以及全胚冷冻后首次冻融胚胎移植病人的一般资料、内膜准备情况、胚胎移植情况及临床结局。结果 早卵泡期长效长方案组的促性腺激素（Gn）总量、Gn天数、扳机日雌二醇浓度、内膜厚度、获卵数均大于拮抗剂组（P0.05）。新鲜周期中，早卵泡期长效长方案组临床妊娠率和着床率均高于拮抗剂组（55.52%比44.12%，41.13%比30.23%，P0.05）。拮抗剂组扳机日黄体
8、生成素（LH）浓度和新鲜周期取消移植率高于长效长方案组（P0.05）。结论 卵巢正常反应病人新鲜周期胚胎移植应用早卵泡期长效长方案临床妊娠率高，取消移植率低，更能使病人获益；但对于全胚冷冻后首次冻胚移植，两种方案的妊娠结局并无差异。关键词：排卵诱导；早卵泡期长效长方案；拮抗剂方案；体外受精-胚胎移植/卵胞浆内单精子注射；卵巢正常反应；临床结局Comparison of the effects of two kinds of superovulation programmes for patients with normal ovarian response undergoing in vitr
9、o fertilization-embryo transfer/intracytoplasmic sperm injectionLYU Xiaojing1,FENG Wenjuan2,WANG Kai2,ZHANG Yingchun2Author Affiliations:1Clinical Medical School,Weifang Medical University,Weifang,Shandong 261053,China;2Department of Reproductive Medicine,Jinan Central Hospital,Jinan,Shandong 250013
10、,China引用本文：吕小晶，冯文娟，王凯，等.两种超促排卵方案对卵巢正常反应病人体外受精-胚胎移植/卵胞浆内单精子注射的效果比较 J.安徽医药，2023，27（7）：1380-1385.DOI：10.3969/j.issn.1009-6469.2023.07.024.临床医学1380安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2023 Jul，27（7）Abstract：Objective To compare the efficacy of the early follicular phase prolonged protocol an
11、d antagonist protocol in patients with normal ovarian response during pregnancy assisted treatment.Methods The clinical data of patients with normal ovarian response who underwent in vitro fertilization-embryo transfer(IVF-ET)/intracytoplasmic sperm injection(ICSI)in reproductive Medicine Center of
12、Jinan Central Hospital from January 2019 to December 2021 was retrospectively analyzed.A total of 587 cycles were included,including 365 early follicular phase prolonged cycles(the follicular phase prolonged protocol group)and 222 antagonist cycles(antagonist protocol group).The general information,
13、ovulation induction and embryo status,fresh cycle embryo transfer status,clinical outcomes between the two groups and the general data,endometrial preparation,embryo transfer and clinical outcomes of patients with the first frozen-thawing embryo transfer after freeze-all were compared.Results The to
14、tal amount of Gn,Gn days,HCG day estradiol(E2)concentration,endometrial thickness and the number of eggs obtained in the follicular phase prolonged protocol group were higher than those in the antagonist group(P0.05).In fresh cycles,the clinical pregnancy rate and implantation rate in the follicular
15、 phase prolonged protocol group were higher than those in the antagonist group(55.52%vs.44.12%,41.13%vs.30.23%,P0.05).The luteinizing hormone(LH)concentration and transplantation cancellation rate in fresh cycle in the antagonist group were higher than those in the follicular phase prolonged protoco
16、l group(P0.05).Conclusions For patients with normal ovarian response,using the early follicular phase prolonged protocol has a high clinical pregnancy rate and a low cancellation rate in the fresh transfer cycles,which is more beneficial for patients.However,there was no significant difference in pregnancy outcome between the two protocols for the first frozen embryo transfer after freeze-all.Key words：Ovulation induction;The early follicular phase prolonged protocol;GnRH antagonist protocol;In