1、中国实验动物学报 2022 年 12 月第 30 卷第 8 期 Acta Lab Anim Sci Sin,December 2022,Vol.30,No.8behavioral,neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder J.Neurochem Int,2015,91:34-45.52 Kumar H,Sharma B.Minocycline ameliorates prenatal valproic acid indu
2、ced autistic behaviour,biochemistry and blood brain barrier impairments in rats J.Brain Res,2016,1630:83-97.53 Hirsch MM,Deckmann I,Santos-Terra J,et al.Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism J.Neuroph
3、armacology,2020,167:107930.54 Al-Askar M,Bhat RS,Selim M,et al.Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism J.BMC Complement Altern Med,2017,17(1):259.55 Singla R,Mishra A,Joshi R,et al.Inhibition of the ERK1/2 phosphorylation by dextromet
4、horphan protects against core autistic symptoms in VPA induced autistic rats:In silico and in vivo drug repurposition study J.ACS Chem Neurosci,2021,12(10):1749-1767.56 Khera R,Mehan S,Bhalla S,et al.Guggulsterone mediated JAK/STAT and PPAR-Gamma modulation prevents neurobehavioral and neurochemical
5、 abnormalities in propionic acid-induced experimental model of autism J.Molecules,2022,27(3):889.57 Solmaz V,Erdo?an MA,Alnak A,et al.Erythropoietin shows gender dependent positive effects on social deficits,learning/memory impairments,neuronal loss and neuroinflammation in the lipopolysaccharide in
6、duced rat model of autism J.Neuropeptides,2020,83:102073.58 Solmaz V,Tekatas A,Erdo?an MA,et al.Exenatide,a GLP-1 analog,has healing effects on LPS-induced autism model:inflammation,oxidative stress,gliosis,cerebral GABA,and serotonin interactions J.Int J Dev Neurosci,2020,80(7):601-612.收稿日期 2022-05
7、-13一例罕见大熊猫癌症的报道:胰腺导管腺癌(PDAC)大熊猫为我国特有物种,被誉为“中国国宝”。大熊猫对现生环境适应能力不佳是其濒危的重要内在因素之一,其中,疾病死亡也可能引起大熊猫数量减少。胰腺导管腺癌(pancreatic ductal adenocarcinoma,PDAC)属于胰腺癌中较为常见的一种组织分型,恶性程度极高。在人类中,PDAC 的发生率约占胰腺癌的90%以上,但 PDAC 在野生动物中并不常见。本文介绍了一例大熊猫 PDAC 病理诊断案例,以期为今后野生动物肿瘤的诊断提供参考意见。本病例,雌性,死亡时 32 岁。对其进行组织病理学观察,胰腺组织内可见大量泡沫样管状腺癌结
8、构;腺上皮呈透明样,细胞核大小差异明显;腺管结构不规则,呈乳头状生长,乳头表面为单层上皮细胞;部分胰腺导管上皮被高柱状黏液细胞取代,黏液细胞呈假复层样柱状上皮结构。Masson 染色可以更清晰地观察到肿瘤组织中细胞核大小差异明显、核异型性、核分裂像,以及杂乱、不规则的腺管结构。据此初步判定该胰腺为高分化或中分化导管腺癌,伴随胰腺上皮内肿瘤的癌前病变。为进一步进行胰腺导管腺癌与慢性胰腺炎的鉴别诊断,本研究进行了肿瘤特异性标记物 CK7、CK19 免疫组化染色,结果显示胰腺组织 CK7、CK19 呈阳性表达,据此判定该大熊猫患 PDAC。近年来,关于动物原发性 PDAC 的报道较为少见,且报道以胰腺外分泌肿瘤为主,患病动物多见于犬、牛等。野生动物未见相关报道,这可能与野生动物 PDAC 罕见有关。现阶段关于大熊猫疾病的病理报告也很少见,关于大熊猫肿瘤的文章则更少,大熊猫肿瘤的患病风险至今仍是未知数,导致大熊猫肿瘤发生的因素也不清楚,这方面的工作应当进一步推进。该研究成果发表于动物模型与实验医学(英文)期刊(Animal Models and Experimental Medicine,2022,5(6):582-586;https:/doi.org/10.1002/ame2.122699411