1、Cell Signaling Technology 20032016 Cell Signaling Technology,IDirect Stimulatory Modification Direct Inhibitory ModificationMultistep Stimulatory Modification Multistep Inhibitory ModificationTentative Stimulatory Modification Tentative Inhibitory ModificationDirect Inhibitory ModificationMultistep
2、Stimulatory Modification Multistep Inhibitory ModificationTentative Stimulatory Modification Transcriptional Inhibitory ModificationKinase Phosphatase Transcription Factor Caspase Receptor Enzyme pro-apoptotic pro-survival GAP/GEF GTPase G-proteinAcetylaseDeacetylasePathway Diagram KeyAutophagy Sign
3、aling Atg16L1PI3K-I/AktSignalingp53/GenotoxicStressPhagophoreAutophagosomeLysosomeCytoplasmicContentsMitochondrialDamageOxidativeStress-targetsSequestrationFusionAutophagolysosomeMembrane Nucleation MAPK/Erk1/2SignalingAminoAcidsApoptosisRaptorMacroautophagyMitophagyGLPRAS40Beclin-1PI3K Class IIIAMPKLC3-IPE+LC3LC3-IIAtg5Atg14Ambra1RubiconAtg5Atg12Atg12Atg7Bcl-2mTORp150PARLBNIP3PINKParkin Atg16L1Atg10Atg3SQSTM1/p62NBR1ALFY+LC3-IISQSTM1/p62NBR1Ambra1Atg4Atg7ULK1Atg13FIP200AMP:ATPububububBNIP3L/NIX
