1、See online version for abbreviations and references.SnapShot:Cytokines IICristina M.Tato and Daniel J.CuaSchering-Plough Biopharma(Formerly DNAX Research),Palo Alto,CA 94304,USA500 Cell 132,February 8,2008 2008 Elsevier Inc.DOI 10.1016/j.cell.2008.01.002CytokineReceptor SourceTargetsMajor FunctionDi
2、sease AssociationInterleukin(IL)-17AIL17RA or IL17RCTh17 cells and othersMucosal tissues,epithelial and endothelial cells Proinflammatory;protective immunity in lung;tight junction integrity;promotes mobilization of neutrophils and cytokine production by epithelial cells;promotes angiogenesis=suscep
3、tibility to extracellular pathogens =exacerbates organ-specific autoimmune inflammationIL-17B,IL-17C,IL-17D,IL-17E(see IL-25)Intestine and pancreas(17B);thymus and spleen(17C);T cells,smooth muscle cells,epithelial cells(17D)IL-17FIL17RA or IL17RCTh17 cellsMucosal tissues,epithelial and endothelial
4、cellsSimilar function as IL-17A but with 2 logs lower receptor affinityNot well defined.=increases neutrophil recruit-ment at high concentration.IL-18IL18R and IL18-R-AcPMacrophages,othersTh1 cells,NK cells,B cellsProinflammatory;induction of IFN=impairs Th1 responsesIL-19IL20R1 and IL20R2 Monocytes
5、,othersKeratinocytes,other tissuesProinflammatory=psoriasisIL-20IL20R1 or IL22R1 and IL20R2Monocytes,othersKeratinocytes,other tissuesProinflammatory=psoriasisIL-21IL21R and IL2RDifferentiated T helper cells(Th2 and Th17 subsets)T cells,B cells,NK cells,dendritic cells Proliferation of T cells;promo
6、tes differentia-tion of B cells and NK cytotoxicityIL-22IL22R1 and IL10R2;IL22BPTh1 and Th17 cells,NK cellsFibroblasts,epithelial cellsInflammatory,antimicrobial=psoriasisIL-23(p19+p40)IL23R and IL12R1Macrophages and dendritic cellsT cellsInflammatory;promotes proliferation of Th17 cells=susceptibil
7、ity to extracellular pathogens.=exacerbates organ-specific autoimmune inflammation.IL-24IL20R1,IL22R1,IL20R2,other.Intracellular?Monocytes,CD4+T cellsKeratinocytes=antitumor effectsIL-25 IL17RBTh2 cells,mast cellsNon-B,non-T,cKit+,FcR cellsPromotes Th2 differentiation and proliferation=impairs Th2 r
8、esponses to extracellular pathogens such as wormsIL-26IL22R1 and IL10R2Activated T cellsIL-27(p28+EBI3)WSX-1 and gp130Activated dendritic cellsT cells,othersInduction of early Th1 differentiation by stimulating expression of the Tbet transcrip-tion factor;Inhibition of effector Th17 cell responses b
9、y inducing STAT-1-dependent blockade of IL-17 production =immune pathology due to uncontrolled inflamma-tory responseIL-28A/B/IL29(IFN family)IL28R1 and IL10R2Activated subsets of dendritic cells?May promote antiviral responsesIL-30(p28 subunit of IL-27)IL-31IL31R and OSM-RActivated T cellsMyeloid p
10、rogenitors,lung epithelial cells,keratinocytesProinflammatory=atopic dermatitis;allergic asthmaIL-32Induces proinflammatory cytokine productionIL-33ST2 and IL1R-AcPMacrophages,dendritic cellsMast cells,Th2 cellsCostimulation,promotes Th2 cytokine production=atopic dermatitis,allergic asthmaIL-35(p35
11、+EBI3)TregsEffector T cellsImmune suppressionSnapShot:Cytokines IICristina M.Tato and Daniel J.CuaSchering-Plough Biopharma(Formerly DNAX Research),Palo Alto,CA 94304,USA500.e1 Cell 132,February 8,2008 2008 Elsevier Inc.DOI 10.1016/j.cell.2008.01.002AbbreviationsIFN,interferon-gamma;IL,interleukin;T
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