1、世界中西医结合杂志 2023 年第 18 卷第 1 期World Journal of Integrated Traditional and Western Medicine2023，Vol.18，No.1临床研究DOI:10 13935/j cnki sjzx 230130基金项目:苏州市科技计划项目(SYS2020041);张家港市科技支撑计划(社会发展)(ZKS2038);张家港青年科技项目(ZJGQNKJ201929)作者单位:1 张家港市中医医院肺病科，江苏 张家港 215600;2 张家港市中医医院肿瘤科，江苏 张家港 215600通信作者:高海建，Email:haijian201
2、9126 com复肺方辅助 TP 方案治疗中晚期非小细胞肺癌患者的临床疗效及对其血清肿瘤标志物、生活质量的影响曹健1成怡楠1梁小红1高海建2【摘要】目的探讨复肺方辅助 TP 方案(紫杉醇+顺铂)在中晚期非小细胞肺癌(Non small cell lungcancer，NSCLC)中的治疗价值。方法选取 2017 年 1 月2020 年 8 月期间张家港市中医医院收治的中晚期NSCLC 患者 90 例，采用随机数字表法分对照组和试验组，每组各 45 例。两组患者均给予 TP 化疗方案(完成 4 个化疗周期，历时 12 周)，在此基础上，试验组自拟复肺方辅助治疗 12 周。治疗 12 周后，观察比
3、较两组患者肿瘤疗效、中医证候疗效、治疗前后血清肿瘤标志物细胞角蛋白 19 可溶性片段(Cytokeratin 19 soluble fragment，CY-FA21 1)、糖蛋白抗原 125(Glycoprotein antigen 125，CA125)、癌胚抗原(Carcinoembryonic antigen，CEA)水平及生活质量(European Organization for esearch and Treatment of Cancer quality of life questionnaire core 30，EOTC QLQ C30)评分变化、不良反应发生率，随访 12 个月
4、，统计两组患者生存情况。结果(1)肿瘤疗效:治疗后试验组疾病控制率 91 11%(41/45)高于对照组 75 56%(34/45)，差异有统计学意义(P 0 05);试验组治疗总有效率55 56%(25/45)高于对照组 42 22%(19/45)，差异有统计学意义(P 0 05);(2)证候疗效:治疗后试验组中医证候疗效总有效率88 89%(40/45)高于对照组57 78%(26/45)，差异有统计学意义(P 0 05);(3)肿瘤标志物:治疗后两组患者肿瘤标志物均低于治疗前，差异有统计学意义(P 0 05);且试验组低于对照组，差异有统计学意义(P 0 05);(4)生活质量:治疗后两
5、组患者总体健康状况领域、功能领域评分较治疗前升高，症状领域评分较治疗前降低，差异有统计学意义(P 0 05);且试验组总体健康状况领域、功能领域评分高于对照组，症状领域评分低于对照组，差异有统计学意义(P 0 05);(5)毒副作用:试验组血小板减少、白细胞减少、血清肌酐升高、丙氨酸氨基转移酶升高、便秘、口腔炎、周围神经异常发生率均低于对照组，差异有统计学意义(P 0 05);(6)生存情况:试验组中位生存时间较对照组长，且 12 个月生存率较对照组高，差异有统计学意义(P 0 05)。结论复肺方辅助 TP 方案治疗中晚期 NSCLC 效果明显，有利于提高疾病控制率，下调血清肿瘤标志物表达，改
6、善患者生活质量，延长生命期限，且能够降低化疗不良反应发生率。【关键词】中晚期非小细胞肺癌;TP 方案;复肺方;肿瘤标志物;生活质量【中图分类号】734 2【文献标识码】AClinical Efficacy of Fufei ecipe assisted TP egimen in the Treatment of Ad-vanced Non Small Cell Lung Cancer and Its Effect on Serum Tumor Markers andQuality of Life of PatientsCAO Jian1，CHENG Yi nan1，LIANG Xiao hon
7、g1，GAO Hai jian2(1 Pulmonary Disease Department，Zhangjiagang Traditional Chinese Medicine Hospital，Zhangjiagang Jiangsu 215600;2 Oncology Department，Zhangjiagang Traditional Chinese Medicine Hospital，Zhangjiagang Jiangsu 215600)【Abstract】ObjectiveTo investigate the therapeutic value of Fufei ecipe a
8、ssisted TP regimen(paclitaxel+cisplatin)in advanced non small cell lung cancer(NSCLC)MethodsNinety patients with advanced NSCLC treated inPulmonary Disease Department of Zhangjiagang Traditional Chinese Medicine Hospital from January 2017 to August 2020were divided into a control group and an experi
9、mental group by random number table，with 45 cases in each group Both371世界中西医结合杂志 2023 年第 18 卷第 1 期World Journal of Integrated Traditional and Western Medicine2023，Vol.18，No.1groups were given TP chemotherapy(completed 4 cycles of chemotherapy，lasting 12 weeks)，and on this basis，the experi-mental gro
10、up was given the adjuvant therapy of Fufei ecipe for 12 weeks After 12 weeks of treatment，the tumor curativeeffect，traditional Chinese medicine(TCM)syndrome curative effect，levels of serum tumor markers cytokeratin 19 solublefragment(CYFA21 1)，glycoprotein antigen 125(CA125)，and carcinoembryonic ant
11、igen(CEA)，changes in EuropeanOrganization for esearch and Treatment of Cancer quality of life questionnaire core 30(EOTC QLQ C30)scores，andthe incidence of adverse reactions before and after treatment of the two groups were compared Both groups were followed upfor 12 months，and the survival of the t
12、wo groups was analyzed esults(1)In terms of tumor efficacy，the disease controlrate of the experimental group was 91 11%(41/45)，which was higher than that of the control group 75 56%(34/45)，P0 05 The total effective rate of the experimental group was 55 56%(25/45)，which was higher than that of the co
13、ntrolgroup 42 22%(19/45)，P 0 05 (2)In terms of the syndrome efficacies，the total effective rate of TCM syndromes inthe experimental group was 88 89%(40/45)，which was higher than that in the control group 57 78%(26/45)，P 0 05 (3)In terms of tumor markers，the tumor markers in the two groups were decre
14、ased after treatment(P 0 05)，andthe experimental group was lower than the control group(P 0 05)(4)In terms of the quality of life，the overall healthstatus score and functional score in the two groups were higher than those before treatment，and the syndrome score waslower than that before treatment(P
15、 0 05)The overall health status score and functional score in the experimental groupwere higher than those in the control group，whereas the syndrome score was lower than that in the control group(P 0 05)(5)In terms of toxic and side effects，the incidence of thrombocytopenia，leukopenia，elevated serum
16、 creatinine，ele-vated alanine aminotransferase，constipation，stomatitis，and abnormal peripheral nerves in the experimental group were low-er than those in the control group(P 0 05)(6)In terms of the survival，the median survival time of the experimentalgroup was longer than that of the control group，and the 12 month survival rate was higher than that of the control group(P 0 05)ConclusionFufei ecipe assisted TP regimen has a significant effect in the treatment of advancedNSCLC，which is beneficial