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8、rain Behav，2019，9（4）：e01248.DOI：10.1002/brb3.1248.15LIU XY，WU D，WEN S，et al.Mild therapeutic hypothermia protects against cerebral ischemia/reperfusion injury by inhibiting miR-15b expression in rats J.Brain Circ，2017，3（4）：219-226.（收稿日期：2021-09-02，修回日期：2021-10-26）生后早期血小板参数与早产儿支气管肺发育不良的相关性分析史雨璇，殷其改作者
9、单位：徐州医科大学附属连云港医院儿科，江苏 连云港222003通信作者：殷其改，女，主任医师，硕士生导师，研究方向为新生儿疾病，Email：摘要：目的 探讨生后早期血小板参数与早产儿支气管肺发育不良（BPD）的相关性。方法 采用回顾性病例对照研究，收集2013年1月至2020年12月徐州医科大学附属连云港医院新生儿重症监护病房收治的胎龄32周的早产儿的临床一般资料和生后2 h、生后2448 h的血小板参数：血小板计数（PLT）、平均血小板体积（MPV）、血小板压积（PCT）、血小板分布宽度（PDW），根据早产儿是否患有BPD分为BPD与非BPD组，比较两组的一般资料、围产资料、临床特征及血小板
10、参数。采用二元logistic回归分析BPD发生的危险因素，受试者操作特征曲线（ROC曲线）分析血小板参数对BPD的预测价值。结果 两组间生后2 h内PLT、MPV、PCT、PDW比较差异无统计学意义。BPD组生后2448 h内MPV水平高于非BPD组 （10.180.80）fL比（9.430.63）fL，差异有统计学意义；两组间PLT、PCT、PDW差异无统计学意义。多因素logistic回归分析显示出生胎龄小 OR=0.24，95%CI：（0.07，0.87）、CPAP时间长 OR=1.42，95%CI：（1.08，1.87）、机械通气时间长 OR=1.57，95%CI：（1.11，2.2
11、1）、输注红细胞次数多OR=2.28，95%CI：（1.07，4.86）、生后2448 h内MPV大 OR=17.80，95%CI：（2.56，123.90）是发生BPD的独立危险因素。当生后2448 h内MPV的诊断界值为9.6时，预测BPD的灵敏度为77.1%，特异度为64.9%。结论 生后2448 h内较高水平的MPV是发生BPD的独立危险因素。生后2448 h MPV9.6fL可作为32周早产儿BPD发生的较敏感的预测指标。关键词：支气管肺发育不良；平均血小板体积；血小板参数；血小板；早产儿引用本文：史雨璇，殷其改.生后早期血小板参数与早产儿支气管肺发育不良的相关性分析 J.安徽医药，
12、2023，27（2）：340-344.DOI：10.3969/j.issn.1009-6469.2023.02.029.临床医学340安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2023 Feb，27（2）Correlation of early postnatal platelet parameters with bronchopulmonary dysplasia in preterm infantsSHI Yuxuan,YIN QigaiAuthor Affiliation:Department of Pediatrics,The A
13、ffiliated Lianyungang Hospital of Xuzhou Medical University,Lianyungang,Jiangsu 222003,ChinaAbstract：Objective To investigate the correlation between early postnatal platelet parameters and bronchopulmonary dysplasia(BPD)in preterm infants.Methods A retrospective casecontrol study was conducted to c
14、ollect general clinical data and platelet parameters,including platelet count(PLT),mean platelet volume(MPV),platelet accumulation(PCT),and platelet distribution width(PDW),from 2 h after birth and 24 to 48 h after birth of premature infants with gestational age 32 weeks who were admitted to the Neo
15、natal Intensive Care Unit of Lianyungang Hospital Affiliated to Xuzhou Medical University from January 1,2013,to December 30,2020.Preterm infants were divided into BPD and non-BPD groups according to whether they had BPD,and the general data,perinatal data,clinical characteristics and platelet param
16、eters of the two groups were compared.Binary logistic regression was used to analyze the risk factors for the occurrence of BPD,and subject operating characteristic curves(ROC curves)were used to analyze the predictive value of platelet parameters for BPD.Results The differences in PLT,MPV,PCT,and PDW within 2 h after birth were not statistically significant between the two groups.The level of MPV within 24-48 h after birth in the BPD group was higher than that in the non-BPD group(10.180.80)fL
