1、4 1 JANUARY 2016 VOL 351 ISSUE 6268sciencemag.org SCIENCE1 JANUARY 2016 VOLUME 351 ISSUE 6268CONTENTS34Light-harvesting dots on microbesNEWSIN BRIEF8 News at a glanceIN DEPTH 10 RESEARCH AGENCIES REVEL IN FINAL 2016 BUDGETNIH gets$2 billion hike,NASA and DOE science grow,NSF avoids restrictive langu
2、age By J.Mervis12 AS EBOLA EPIDEMIC DRAWS TO A CLOSE,A THIN SCIENTIFIC HARVESTThirteen clinical trials in West Africa have yielded only one unequivocally positive result By J.Cohen and M.Enserink13 SPERM RNA FRAGMENTS MODIFYOFFSPRING METABOLISMMolecules transfer mouse paternal parental traits to pro
3、geny By M.Leslie14 FUNDING FOR KEY DATA RESOURCES IN JEOPARDYNIH genome institute wants to scale back support of human and model organism databases By J.Kaiser15 CALIFORNIA STEM CELL AGENCY PLOTS A RACE TO THE CLINICCIRM lays out endgame and prospects for new money By K.ServickFEATURE 16 UNFILLED VI
4、ALSScientifically feasible vaccines against major diseases are stalled for lack of funds.Science names 10 top candidates that need a boost By J.CohenINSIGHTSLETTERS 20 NEXTGEN VOICES:POLITICAL PRIORITIES PERSPECTIVES 24 ILLUMINATING ANHEDONIAOptogenetics and fMRI reveal the brain circuitry of anhedo
5、nia By T.W.Robbins REPORT P.4125 SEEING mTORC1 SPECIFICITYStructural information reveals how a multiprotein complex responds to amino acid abundance By G.R.Buel and J.Blenis RESEARCH ARTICLES PP.43,48,&5326 WHEN TWO REACTIONS BECOME ONEMerging two fundamental reactions of organoboron compounds provi
6、des a new platform for catalysis By J.W.B.Fyfe and A.J.B.Watson REPORT P.7028 THE EVOLUTION OF ANTIEVOLUTION POLICIES AFTER KITZMILLER V.DOVERA phylogeny identifies ancestors of modern creationist legislation By N.J.Matzke30 THE SCREAMS OF A STAR BEING RIPPED APARTA star being devoured by a black ho
7、le provides a route to study accretion and jet formation By G.C.Bower REPORT P.6232 THE POWER OF CROWDSCombining humans and machines can help tackle increasingly hard problems By P.Michelucci and J.L.Dickinson34 MICROBES IN A KNIGHTS ARMORBacteria studded with nanoparticles produce acetate from carb
8、on dioxide and sunlight By V.Mller REPORT P.74BOOKS ET AL.35 NEWTONS APPLE ANDOTHER MYTHS ABOUT SCIENCER.L.Numbers and K.Kampourakis,Eds.reviewed by J.Endersby1535Published by AAAS1 JANUARY 2016 VOL 351 ISSUE 6268 5SCIENCE sciencemag.org84More precise genome editing48A complex key to growth and meta
9、bolismRESEARCHIN BRIEF 37 From Science and other journalsREVIEW40 ANTIBIOTIC RESISTANCEMultidrug evolutionary strategies to reverse antibiotic resistance M.Baym et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aad3292RESEARCH ARTICLES 41 NEURAL CIRCUITSPrefrontal cortical regulation of
10、brainwide circuit dynamics and reward-related behavior E.A.Ferenczi et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aac9698 PERSPECTIVE P.2442 BEHAVIORAL GENETICSEpigenetic(re)programming of caste-specific behavior in the ant Camponotus floridanus D.F.Simola et al.RESEARCH AR
11、TICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aac6633 VIDEOMETABOLISM 43 Sestrin2 is a leucine sensor for the mTORC1 pathway R.L.Wolfson et al.48 Architecture of human mTOR complex 1 C.H.S.Aylett et al.53 Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway R.A.Saxton et al.P
12、ERSPECTIVE P.25REPORTS 58 3D PRINTINGAdditive manufacturing of polymer-derived ceramics Z.C.Eckel et al.VIDEO62 BLACK HOLE PHYSICSA radio jet from the optical and x-ray bright stellar tidal disruption flare ASASSN-14li S.van Velzen et al.PERSPECTIVE P.3065 ASTROCHEMISTRYStatistical ortho-to-para rat
13、io of water desorbed from ice at 10 kelvin T.Hama et al.68 MEMBRANESSieving hydrogen isotopes through two-dimensional crystals M.Lozada-Hidalgo et al.70 ORGANIC CHEMISTRYCatalytic conjunctive cross-coupling enabled by metal-induced metallate rearrangement L.Zhang et al.PERSPECTIVE P.2674 MICROBIAL E
14、NGINEERINGSelf-photosensitization of nonphotosynthetic bacteria for solar-to-chemical production K.K.Sakimoto et al.PERSPECTIVE P.34VIROLOGY 77 An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels B.L.Haagmans et al.81 Co-circulation of three camel coro
15、navirus species and recombination of MERS-CoVs in Saudi Arabia J.S.M.Sabir et al.84 GENOME EDITINGRationally engineered Cas9 nucleases with improved specificity I.M.Slaymaker et al.88 PROTEIN TRANSLOCATIONStructure of the Sec61 channel opened by a signal sequence R.M.Voorheees and R.S.HegdeDEPARTMEN
16、TS7 EDITORIAL New members of the familyBy Marcia McNutt98 WORKING LIFEBeyond the tick boxesBy Artaza GilaniON THE COVERVials of experimental vaccines against severe acute respiratory syndrome,Marburg virus,and chikungunya sit on ice at the Vaccine Pilot Plant run by the U.S.National Institutes of Health in Frederick,Maryland.In the wake of the Ebola epidemic in West Africa,a growing number of researchers and public health advocates are arguing that more should be done to aggressively advance vac
