1、CREDITS(FROM TOP):N.DESAI/SCIENCE;NASA/JPL-CALTECH30 NOVEMBER 2018 VOL 362 ISSUE 6418 971SCIENCE sciencemag.org30 NOVEMBER 2018 VOLUME 362 ISSUE 6418CONTENTS999The mechanics of metastasisNEWSIN BRIEF976 News at a glanceIN DEPTH 978 SHOCK GREETS CLAIM OF CRISPR-EDITED BABIESApparent germline engineer
2、ing by Chinese researcher prompts outrage and investigations By D.Normile979 SAFELY SETTLED,INSIGHT GETS READY TO LOOK INSIDE MARSLander will deploy seismometer and heat probe to listen for marsquakes and study the planets interior By P.Voosen980 MIGRANTS AND TRADE SPICED UP CANAANITE METROPOLISIn B
3、ronze Age tombs,signs of vanilla,3000 years early,and elaborate medical care By A.Lawler982 CHINA SETS OUT FOR THE FAR SIDE OF THE MOONLatest mission in ambitious program is a boon for lunar geology and radio astronomy By D.NormileINSIGHTSPERSPECTIVES 992 THE LAST OF ASIA CONQUERED BY HOMO SAPIENSEx
4、cavation reveals the earliest human colonization of the Tibetan Plateau By J.-F.Zhang and R.Dennell REPORT P.10499Theof 979983 EUROPEAN FUNDERS DETAIL THEIR OPEN-ACCESS PLANPlan S will allow researchers to publish in hybrid journals that commit to flip to full open access By T.RabesandratanaFEATURES
5、 984 FORGOTTEN NO MORE A long-overlooked scourge of millions,hepatitis B is in the crosshairs at last By J.Cohen988 BUYING TIMEIn a fast-changing environment,evolution can be too slow.“Plasticity”can give it a chance to catch up By E.Pennisi PODCAST994 NEW DIMENSIONS FOR BRAIN MAPPINGImaging reveals
6、 new features of memory representation in the brain By Y.Assaf REPORT P.1045995 CLUES FROM GAMMA RAYS ONTHE HISTORY OF STAR BIRTHThe rate of star formation peaked 10 billion years ago By E.Prandini REPORT P.1031996 ONE CRYSTAL OUT OF MANYFast-moving grain boundaries convert a hanging polycrystalline
7、 metal foil into a single crystal By A.Rollett RESEARCH ARTICLE P.1021998 CULTURE AND CONFORMITY SHAPEFRUITFLY MATINGPotent social learning sustains the inheritance of mating preferences over generations By A.Whiten RESEARCH ARTICLE P.1025999 METASTASES GO WITH THE FLOWBlood flow mechanics influence
8、 metastatic efficiency By J.G.Goetz1001 LEON MAX LEDERMAN(19222018)Charismatic particle physics pioneer By R.KolbPOLICY FORUM 1002 THE CASE FOR MONITORINGLIFE-SPAN INEQUALITYFocus on variation in age at death,not just average age By A.A.van Raalte et al.BOOKS ET AL.1005 PLAYING WITH PARTICLE PHYSICS
9、The quantum realm comes to life in a fast-paced new board game By A.Chuang1006 THE MYTH OF APOLITICAL SCIENCEDenouncing state-controlled research,U.S.investigators advanced the American agenda during the Cold War By A.WellersteinLETTERS 1007 PREPARE FOR CASCADIAS NEXT EARTHQUAKEBy B.A.Leshchinsky et
10、 al.Newly arrived lander gets set to deploy instruments on Mars.Published by AAASon December 4,2018 http:/science.sciencemag.org/Downloaded from IMAGE:LEE ET AL.30 NOVEMBER 2018 VOL 362 ISSUE 6418 973SCIENCE sciencemag.orgCONTENTS30 NOVEMBER 2018 VOLUME 362 ISSUE 6418RESEARCHIN BRIEF 1014 From Scien
11、ce and other journalsREVIEW1017 MICROBIOTAColonocyte metabolism shapes the gut microbiota Y.Litvak et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat9076RESEARCH ARTICLES 1018 STRUCTURAL BIOLOGYSubstrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysisdriven tran
12、slocation A.H.de la Pea et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aav07251019 BIOCHEMISTRYFormyl-methionine as an N-degron of a eukaryotic N-end rule pathway J.-M.Kim et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat01741020 STRUCTURAL BIOLOGYA
13、n electron transfer path connects subunits of a mycobacterial respiratory supercomplex H.Gong et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat89231021 METALLURGYColossal grain growth yields single-crystal metal foils by contact-free annealing S.Jin et al.PERSPECTIVE P.9961
14、025 ANIMAL CULTURECultural flies:Conformist social learning in fruitflies predicts long-lasting mate-choice traditions E.Danchin et al.PERSPECTIVE P.998;VIDEOREPORTS 1031 COSMOLOGYA gamma-ray determination of the Universes star formation history The Fermi-LAT Collaboration PERSPECTIVE P.995;PODCAST1
15、034 DISTANT GALAXIESThe multiple merger assembly of a hyperluminous obscured quasar at redshift 4.6 T.Daz-Santos et al.1037 SOLID-STATE PHYSICSIsostructural metal-insulator transition in VO2 D.Lee et al.1040 SUPERCONDUCTIVITYUniaxial pressure control of competing orders in a high-temperature superco
16、nductor H.-H.Kim et al.1045 NEUROSCIENCEFast track to the neocortex:A memory engram in the posterior parietal cortex S.Brodt et al.PERSPECTIVE P.9941049 ARCHAEOLOGYThe earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago X.L.Zhang et al.PERSPECTIVE P.9921052 MATERNAL CAREProlonged milk provisioning in a jumping spider Z.Chen et al.VIDEO1055 CANCERHuman tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma J.Ablai
