1、Cell Signaling Technology 20032018 Cell Signaling Technology,IDirect Stimulatory Modification Direct Inhibitory ModificationMultistep Stimulatory Modification Multistep Inhibitory ModificationTentative Stimulatory Modification Tentative Inhibitory ModificationTranscriptional Inhibitory ModificationP
2、athway Diagram KeyAngiogenesisVHLCul2Rbx1TCEB2TCEB1PHDselF4E14E-BP1Erk1/2Erk1/2MNKMEK1/2RasS6KmTORAktPI3KCBP/p300HIF1HIF1HIF1HIF1HIF1PI3KSrcNOSAktFAKPLCErk1/2Smad2/3p38 MAPKHIF1HIF1Matrix RemodelingPAI-1MMPCox2OHOHOHNormoxiaNucleusVEGFR2VEGFTie2FGFRIGFREGFRPDGFR-PDGF-BBROBOSLITNotchE3 Ligase Complex
3、Degradation Growth Factors Cytokines ECM ProteasesExtracellularMatrixEndothelial CellPericyteNormoxiaNormoxiaHypoxiaBlood VesselVascularGuidanceCell FateVascularPermeabilitySurvivalMigrationProliferationPericyteProliferationTarget GenesHREBasement MembraneCytoplasmPro-Angiogenic CellExtracellular Spacerev.08/24/18
