1、NUCLEUSCYTOPLASMSTAT3STAT3PEGFRLIFRgp130IL-6RCytokines&Growth Factors(EGF,PDGF,LIF,IL-6)JAK-STAT?-SecretaseNotch Intracellular Domain NICDNotchNotchDelta,JaggedProteolytic cleavage by?-Secretase&MetalloproteasesNUMBTranslocationShhPatchedSmoSmoIntracellularVesicleGliHedgehog SUFUGSK-3?PKALRPFrizzled
2、WntR-spondinWnt?-CatGSK-3?-Cat?-Cat?-CatAxinAPCDshAxinGSK-3?CK1Degradation?CatMAPK/ERKP?-CatUbUbUbUbPPPCytokines&Survival Factors(IGFs,FGFs)RTKSmadTGF-?BMPActivin/NodalALK2ALK3ALK6ALK4ALK7ALK1ALK5TGF-?RIIActR-IIAActR-IIBPPPPSmad2/3Smad1/5/8Smad6/7Smad2/3Smad1/5/8PSmad4Smad1/5/8Smad1/5/8PPSmad4Smad2/
3、3Smad2/3PPPI3K NF-?BPPSOSFrs2Grb2RasRafMAPK/ERKMKP1-3RIN1RKIPRTKCytokines&Growth Factors(EGF,FGFs,PDGF)PI3KPPPIP3PIP2PPPPPAKTAKTPSHIP1/PTENStemness Maintenance,Survival,ProliferationMDM2p53GSK-3?BadApoptosisI?BNF-?BI?BPNF-?BNF-?B Familyp50/p150p52/p160C-Rel,RelA,RelBOxidative Stress,Infections,TNF-?
4、,IL-1,Growth Factors?-CatTCF/LefGliMAMLCSLSTAT3PSTAT3PJunFosMAPK/ERKPNF-?BAcStemness Maintenance,Survival,Proliferation,DifferentiationPPJAKPSmad4IKKBMPR-IIActR-IIAActR-IIBLGRSmad4TFSmad1/5/8PSmad4TFSmad2/3PNICDCancer&Stem Cell Signaling PAdipogen InternationalSchtzenstrasse 12?CH-4410 Liestal?Switzerland TEL:+41-61-926-60-40?FAX:+41-61-926-60-49E-Mail:? APR 2013
