1、Kinase Phosphatase Transcription Factor Caspase Receptor Enzyme pro-apoptotic pro-survival GAP/GEF GTPase G-proteinAcetylaseDeacetylaseRibosomal subunitDirect Stimulatory Modification Direct Inhibitory ModificationMultistep Stimulatory Modification Multistep Inhibitory ModificationTentative Stimulat
2、ory Modification Tentative Inhibitory ModificationSeparation of Subunits or Cleavage Products Joining of SubunitsTranslocation Transcriptional Stimulatory Modification Transcriptional Inhibitory ModificationCELL SIGNALING TECHNOLOGYPathway Diagram Keys UbUbUbUbUbUbUbUbUbE1E2E1E2E2E3DUBE3ProteinSubst
3、rateATPAMP26SProteasomePeptidesADPATPProteinSubstrateMultipleCyclesProteinSubstrateProteinSubstrate19S20S19SE3 Ubiquitin Ligasesc-Cbl N-Terminalc-Cbl(906 aa)RINGUBAEFEF-TrCP(605 aa)WD DomainsF-boxSkp2(424 aa)F-boxLRR RepeatsNEDD4(1319 aa)WW DomainsHECTUbiquitin/Proteasome 2004 2014 Cell Signaling Technology,Inc.
