1、1 APRIL 2016 VOL 352 ISSUE 6281 5SCIENCE sciencemag.org1 APRIL 2016 VOLUME 352 ISSUE 6281CONTENTS35&95 Nursing mouse eggsto maturity NEWSIN BRIEF12 News at a glanceIN DEPTH 15 EL NIOS WARMTH DEVASTATING REEFS WORLDWIDERecent aerial surveys of Australias Great Barrier Reef fi nd massive coral bleachi
2、ng By D.Normile16 SANDY RIPPLES POINT TO MARSS PASTUnique dune features emerge from rovers campaign in the sand By E.Hand18 BRAZIL BILL WOULD LEGALIZE RENEGADE CANCER PILLGovernment races to put“fosfo”through clinical testing By H.Escobar19 CANADIAN SCIENTISTS SMILE AT LIBERALS DJ VU BUDGETTrudeau o
3、f ers warm support for basic research By W.Kondro20 NO-STRINGS AWARDS AT NIH DRAW CONCERNSome recipients say they didnt expect deep cuts in funding By J.KaiserFEATURES 21 IMMUNITY GOES LOCALSimilar to lymph nodes,but transient,tertiary lymphoid structures can drive immune responses By M.LeslieINSIGH
4、TSLETTERS 28 NEXTGEN VOICESPERSPECTIVES 31 MITOCHONDRIAL DISEASE THERAPY FROM THIN AIR?Low-oxygen treatment slows neurodegeneration in a model of a mitochondrial disorder By E.A.Shoubridge RESEARCH ARTICLE P.5432 RETHINKING THE SN2 REACTIONThe gas-phase dynamics of a paradigm organic reaction are mo
5、re complex than expected By J.Xie and W.L.Hase34 HOW ANTARCTICA GOT ITS ICEA complex set of interactions caused the rapid growth of the Antarctic ice sheet 34 million years ago By C.H.Lear and D.J.Lunt REPORT P.7635 NURSING THE OOCYTEMammalian egg cells receive material from neighboring“nurse”cells
6、via bridges and gaps By M.E.Pepling REPORT P.9537 AN ODD ONE OUTAn oxygen-rich white dwarf sets an important mark for stellar evolution By B.Gnsicke REPORT P.6738 ENGAGE KEY SOCIAL CONCEPTS FOR SUSTAINABILITYSocial indicators,both mature and emerging,are underused By C.C.Hicks et al.40 COLLOIDAL CRY
7、STAL ORDERING IN A LIQUID CRYSTALA nematic phase promotes the formation of dilute,low-symmetry colloidal crystals By C.Blanc REPORT P.6942 A BRAIN CONDITIONED FOR SOCIAL DEFEATA brain circuit in vertebrates determines who wins or loses a fi ght By L.Desban and C.Wyart REPORT P.8743 A lncRNA LINKS GE
8、NOMICVARIATION WITH CELIAC DISEASEA long noncoding RNA is associated with an intestinal autoimmune disorder By M.Huarte REPORT P.9144 GOING WITH THE FLOWA desktop machine allows on-demand medicine production By R.E.Martin RESEARCH ARTICLE P.61BOOKS ET AL.46 BOYBy A.Ziegler;directed by L.Firman,revie
9、wed by O.Vikbladh47 LAB GIRLBy H.Jahren,reviewed by M.Lowman35&Nursing mousto maturity324 OCCUPATIONAL HAZARDFarm workers are dying in southernIndia as an epidemic of a mysteriouskidney disease goes global By R.Chatterjee24Science Staf .8New Products.104Science Careers.106DEPARTMENTS11 EDITORIAL New
10、 frontiers in bioscience By Paul G.Allen110 WORKING LIFEOf mice and micsBy Adam RubenPublished by AAASon March 31,2016Downloaded from on March 31,2016Downloaded from 1 APRIL 2016 VOL 352 ISSUE 6281 7SCIENCE sciencemag.orgCONTENTS40&69Orienting nanorods in liquid crystals 1 APRIL 2016 VOLUME 352 ISSU
11、E 6281RESEARCHIN BRIEF 48 From Science and other journalsREVIEW51 CELL DEATH PATHWAYSProgrammed necrosis in infl ammation:Toward identifi cation of the ef ector molecules D.Wallach et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf2154RESEARCH ARTICLES 52 NONHUMAN GENOMICSLong-read se
12、quence assembly of the gorilla genome D.Gordon et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aae034453 SYNTHETIC BIOLOGYGenetic circuit design automation A.A.K.Nielsen et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aac734154 MITOCHONDRIAL DISEASEHyp
13、oxia as a therapy for mitochondrial disease I.H.Jain et al.PERSPECTIVE P.3161 FLOW CHEMISTRYOn-demand continuous-fl ow production of pharmaceuticals in a compact,reconfi gurable system A.Adamo et al.PERSPECTIVE P.44;PODCASTREPORTS 67 STELLAR EVOLUTIONA white dwarf with an oxygen atmosphere S.O.Keple
14、r et al.PERSPECTIVE P.3769 COLLOIDAL ORDERINGTriclinic nematic colloidal crystals from competing elastic and electrostatic interactions H.Mundoor et al.PERSPECTIVE P.4073 ELECTROCATALYSISTuning the activity of Pt alloy electrocatalysts by means of the lanthanide contraction M.Escudero-Escribano et a
15、l.76 ICE SHEETSAntarctic Ice Sheet variability across the Eocene-Oligocene boundary climate transition S.Galeotti et al.PERSPECTIVE P.3480 ATMOSPHERIC METHANEA 21st-century shift from fossil-fuel to biogenic methane emissions indicated by 13CH4 H.Schaefer et al.84 CLIMATE CHANGEConsistent response o
16、f bird populations to climate change on two continents P.A.Stephens et al.87 CONFLICT BEHAVIORSocial confl ict resolution regulated by two dorsal habenular subregions in zebrafi sh M.-Y.Chou et al.PERSPECTIVE P.4291 IMMUNE REGULATIONA long noncoding RNA associated with susceptibility to celiac disease A.Castellanos-Rubio et al.PERSPECTIVE P.4395 MAMMALIAN GERM CELLSMouse oocytes dif erentiate through organelle enrichment from sister cyst germ cells L.Lei and A.C.Spradling PERSPECTIVE P.3599 IMMU
