1、14-3-3TopoIIp21Cip1CDK714-3-3Boracdc25cdc25A/Ccdc25A/BPLK1Myt1Wee1p90RSKATM/ATRMre11NBS1Rad52Chk2c-AblPOT1 TRF2Chk1DNA-PKcdc25Acdc2Cyclin Bp53p53MDM2MDM4MDM2AurATRIP12BRCA1BRCA1BRCA1FANCD2Rad50ReprimoGADD45Rad51HIPK2p300/PCAFSCFSCFp19ArfIRUVCritically ShortTelomeresDNA RepairCaffeine(MRN)DNARepairNu
2、clear ExclusionNuclearExclusionNucleolar Sequestration orp53 StabilizationNuclear Export,UbiquitinationUbiquitinationUbiquitinationG2-PHASE M-PHASECell Cycle Control:G2/M DNA Damage C 2002 2010 Cell Signaling Technology,Inc.Cell Cycle Control:G2/M DNA Damage Checkpoint created November 2002 revised
3、November 2010Direct Stimulatory ModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomal subunitTranscription FactorTranscriptional StimulationTranscriptional InhibitionTranslocationSeparation of Subunits or Cleavage ProductsJoining of SubunitsDirect Inhibitory ModificationMultistep Stimulatory ModificationMultistep Inhibitory ModificationTentative Stimulatory ModificationTentative Inhibitory ModificationSignaling Pathways K 2003-2010 Cell Signaling Technology,Inc.AcetylaseDeacetylase
