1、VascularGuidanceVascularPermeabilitySurvivalMigrationProliferationVHLCul2Rbx1TCEB2TCEB1UbUbUbUbUbPHDselF4E14E-BP1Erk1/2Erk1/2MNKMEK1/2RasS6KmTORAktPI3KCBP/p300HIF1HIF1HIF1HIF1HIF1PI3KSrcNOSAktFAKPLCErk1/2Smad2/3p38 MAPKHIF1HIF1NucleusHRETarget GenesMatrix RemodelingCytoplasmPAI-1MMPCox2NormoxiaOHOHO
2、HTumor CellVEGFR2VEGFPericyteProliferationTie2FGFRIGFRTGF-RPDGFR-PDGF-BBROBOSLITE3 Ligase ComplexDegradation Growth Factors Cytokines ECM ProteasesExtracellularMatrixEndothelial CellCytoplasmPericyteExtracellular Space 2008 2010 Cell Signaling Technology,Inc.Angiogenesis created September 2008 revis
3、ed March 2011ADirect Stimulatory ModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomal subunitTranscription FactorTranscriptional StimulationTranscriptional InhibitionTranslocationSeparation of Subunits or Cleavage ProductsJoining of SubunitsDirect Inhibitory ModificationMultistep Stimulatory ModificationMultistep Inhibitory ModificationTentative Stimulatory ModificationTentative Inhibitory ModificationSignaling Pathways K 2003-2010 Cell Signaling Technology,Inc.AcetylaseDeacetylase
