1、NIKTAK1TRAF2TRADDFADDPTENPIP3RasSrcJakRafPKCErk1/2PKAp70S6KBadp90RSKCREBStat1Stat3CREBStat1Stat3Bcl-xLBcl-2Cyto cApaf-1HSP70HSP90HSP90HSP90HSP27HSP27IKKIBNF-BIBFoxO1FoxO1FoxO1Casp-3,-6,-7Casp-9Casp-8,-10A20CYLDGSK-3JNKXIAPNF-BNF-BAktAktPDK1PI3KTNF-R1TNF-HSP90HSP70IKKIKKIKKIKKCDC37TABcIAPtBIDBaxBaxBa
2、xFLIPMcl-1HECTH9BimBIDBimBimHSP70HSP27HSP90Smac/DiablocAMPRIPSurvival Factors:Growth Factors,Cytokines,etc.ApoptosisFASBimBcl-2Bcl-xLFLIPXIAPA20CytoplasmCytoplasmNucleus 2002 2010 Cell Signaling Technology,Inc.Inhibition of Apoptosis created January 2002 revised November 2010Inhibition of ADirect St
3、imulatory ModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomal subunitTranscription FactorTranscriptional StimulationTranscriptional InhibitionTranslocationSeparation of Subunits or Cleavage ProductsJoining of SubunitsDirect Inhibitory ModificationMultistep Stimulatory ModificationMultistep Inhibitory ModificationTentative Stimulatory ModificationTentative Inhibitory ModificationSignaling Pathways K 2003-2010 Cell Signaling Technology,Inc.AcetylaseDeacetylase
