1、Designation:D583608(Reapproved 2013)Standard Test Method forDetermination of 2,4-Toluene Diisocyanate(2,4-TDI)and 2,6-Toluene Diisocyanate(2,6-TDI)in Workplace Atmospheres(1-2 PP Method)1This standard is issued under the fixed designation D5836;the number immediately following the designation indica
2、tes the year oforiginal adoption or,in the case of revision,the year of last revision.A number in parentheses indicates the year of last reapproval.Asuperscript epsilon()indicates an editorial change since the last revision or reapproval.1.Scope1.1 This test method describes the determination of 2,4
3、-toluene diisocyanate(2,4-TDI)and 2,6-toluene diisocyanate(2,6-TDI)in air samples collected from workplace atmo-spheres in a cassette containing a glass-fiber filter impregnatedwith 1-(2-pyridyl)piperazine(1-2 PP).This procedure is veryeffective for determining the vapor content of atmospheres.Atmos
4、pheres containing aerosols may cause TDI results to beunderestimated.1.2 This test method uses a high-performance liquid chro-matograph(HPLC)equipped with a fluorescence or an ultra-violet(UV)detector(1-4).2,31.3 The validated range of the test method,as written,isfrom 1.4 to 5.6 g of 2,4-TDI and 2,
5、6-TDI which is equivalentto approximately 9.8 to 39 ppb for 2,4-TDI and 2,6-TDI basedon a 20-L air sample.The HPLC method using an UV detectoris capable of detecting 0.078 g of 2,4-TDI and 0.068 g of2,6-TDI in a 4.0-mL solvent volume,which is equivalent to0.55 ppb for 2,4-TDI and 0.48 ppb for 2,6-TD
6、I based on a 20-Lair sample.1.4 The isomers of 2,4-TDI,and 2,6-TDI,can be separatedutilizing a reversed phase column for the HPLC method.Because industrial applications employ an isomeric mixture of2,4-and 2,6-TDI,the ability to achieve this separation isimportant.1.5 The values stated in SI units a
7、re to be regarded asstandard.No other units of measurement are included in thisstandard.1.6 This standard does not purport to address all of thesafety concerns,if any,associated with its use.It is theresponsibility of the user of this standard to establish appro-priate safety and health practices an
8、d determine the applica-bility of regulatory limitations prior to use.See Section 9 forspecific precautions.2.Referenced Documents2.1 ASTM Standards:4D1193 Specification for Reagent WaterD1356 Terminology Relating to Sampling and Analysis ofAtmospheresD1357 Practice for Planning the Sampling of the
9、AmbientAtmosphereD3686 Practice for Sampling Atmospheres to Collect Or-ganic Compound Vapors(Activated Charcoal Tube Ad-sorption Method)E691 Practice for Conducting an Interlaboratory Study toDetermine the Precision of a Test Method3.Terminology3.1 For definitions of terms used in this test method,r
10、efer toTerminology D1356.4.Summary of Test Method4.1 A known volume of air is drawn through a cassettecontaining a glass-fiber filter impregnated with 1-(2-pyridyl)piperazine.The diisocyanate reacts with the secondaryamine to form a urea derivative.4.2 The coated glass-fiber filter is extracted with
11、 acetonitrile(ACN)containing 10%dimethyl sulfoxide(DMSO)and theextract is analyzed by HPLC.The eluent is monitored with afluorescence detector(240-nm excitation,370-nm emissioncutoff filter)or a UV detector(254 nm).1This test method is under the jurisdiction of ASTM Committee D22 on AirQuality and i
12、s the direct responsibility of Subcommittee D22.04 on Workplace AirQuality.Current edition approved April 1,2013.Published April 2013.Originallyapproved in 1995.Last previous edition approved in 2008 as D5836-08.DOI:10.1520/D5836-08R13.2Validation data and a preliminary draft of this test method wer
13、e provided by theSalt Lake Technical Center of the U.S.Dept.of Labor,Occupational Safety andHealth Administration,Salt Lake City,UT.3The boldface numbers in parentheses refer to the references at the end of thistest method.4For referenced ASTM standards,visit the ASTM website,www.astm.org,orcontact
14、ASTM Customer Service at serviceastm.org.For Annual Book of ASTMStandards volume information,refer to the standards Document Summary page onthe ASTM website.Copyright ASTM International,100 Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959.United States1 4.3 The amount of the urea deriva
15、tive collected is deter-mined by comparison of sample response(peak area integra-tions or peak heights)to a standard calibration curve for theurea derivative.4.4 The amount of diisocyanate is calculated from theamount of urea determined in the analysis.5.Significance and Use5.1 Diisocyanates are use
16、d in the production of polyure-thane foams,plastics,elastomers,surface coatings,and adhe-sives(5,6).It has been estimated that the production of TDIwill steadily increase during the future years.5.2 Diisocyanates are irritants to eyes,skin,and mucousmembrane and are respiratory sensitizers.Chronic exposure tolow concentrations of diisocyanates produces an allergic sen-sitization which may progress into asthmatic bronchitis(7,8).5.3 The Occupational Safety and Health Administration(OSHA)has a per
